Deputy Manager / Manager (Manufacturing Sciences)
Navi Mumbai, Maharashtra Job ID R0188593 Category Manufacturing Sciences Subcategory Manufacturing & Supply Business Unit Global Manufacturing & Supply Job Type Full timeBy clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.
Job Description
Shape the future of manufacturing at Zydus Takeda.
Join our MSAT team as a Deputy Manager/Manager and turn scientific innovation into robust, scalable processes that help deliver life-changing medicines to patients worldwide.
Here is exciting job opportunity for you !
Zydus Takeda Healthcare Pvt. Ltd. is a strategic joint venture between Zydus Healthcare Ltd., a leading Indian pharmaceutical company with a global presence, and Takeda Pharmaceuticals, Japan’s largest pharmaceutical company with operations worldwide. Combining strong local expertise with global innovation, the company is committed to delivering high-quality healthcare solutions and improving patient lives. We are located at Navi Mumbai location.
Position - Deputy Manager / Manager - Manufacturing Sciences & Analytical Technology (MSAT)
Education & Experience – M.Sc. / Ph.D. in Organic Chemistry, Medicinal Chemistry, Pharmaceutical Chemistry or equivalent
Job description:
1. Role Purpose:
The incumbent will be responsible for synthetic process development, reaction optimization, scale-up, process characterization, Life Cycle Management (LCM), technology transfer and manufacturing support for APIs and intermediates.
The role requires strong hands-on expertise in synthetic organic chemistry, coupled with an understanding of process robustness, scale-up, process safety, GMP requirements, data-driven optimization, and manufacturability. The incumbent will also contribute to the development of flow chemistry, process intensification and continuous manufacturing capabilities within MSAT.
2. Key Roles & Responsibilities:
A. Process Development & Synthetic Chemistry
- Independently design and execute synthetic routes, reaction optimization and process development studies for APIs/intermediates.
- Investigate reaction chemistry, kinetics, selectivity, impurity formation and process parameters.
- Identify opportunities for improvement in yield, quality, cycle time, solvent/reagent consumption, cost and waste generation.
- Conduct LCM and process improvement studies and establish robust and scalable processes.
- Evaluate alternative synthetic routes, reagents, catalysts and solvents considering technical, economic, safety and sustainability aspects.
B. Process Optimization & Data Analytics
- Design and execute structured experiments using DoE, statistical tools and data-driven approaches.
- Identify critical process parameters (CPPs), process risks and their impact on product quality.
- Interpret experimental, analytical and manufacturing data to identify trends, variability and root causes.
- Translate laboratory findings into practical and scalable manufacturing solutions.
C. Scale-Up & Manufacturing Support
- Develop processes with scale-up and manufacturability considerations from the early stages.
- Support laboratory-to-kilo/pilot/commercial scale-up and engineering/validation batches.
- Provide technical support for manufacturing deviations, process failures, yield losses, impurity excursions and atypical results.
- Participate in troubleshooting and implementation of process improvements at manufacturing scale.
- Assess equipment capability, mixing, heat/mass transfer and other scale-dependent process challenges.
D. Flow Chemistry & Continuous Manufacturing
- Understand principles of batch, flow and continuous manufacturing.
- Evaluate reaction suitability for flow processing based on kinetics, heat/mass transfer, mixing, residence time, pressure, solid formation and reaction hazards.
- Select and utilize appropriate flow platforms/reactors based on reaction characteristics.
- Support development of flow chemistry/process intensification solutions and assess their potential for scale-up and commercial application.
E. Process Safety, EHS & Sustainability
- Identify process safety risks during laboratory and scale-up studies, including exothermicity, gas evolution, pressure, thermal instability, hazardous intermediates and decomposition risks.
- Work with EHS/Engineering teams on process safety assessments such as FMEA, HAZOP/HAZID, calorimetry and LOPA, as applicable.
- Incorporate inherently safer chemistry, solvent reduction, waste minimization and energy-efficient approaches into process development.
F. Technology Transfer & GMP
- Support technology transfer of API/intermediate processes from development sites, partners or external organizations.
- Review process descriptions, process flow diagrams, equipment trains, process parameters, IPCs and manufacturing records.
- Identify technology gaps, scale-up risks and process knowledge requirements.
- Contribute to preparation/review of Technology Transfer Protocols/Reports, process development reports, risk assessments and technical documents.
- Execute activities in accordance with cGMP, ICH Q7/Q8/Q9/Q10/Q11 and applicable regulatory requirements.
- Maintain high standards of documentation, data integrity, laboratory practices and scientific traceability.
- Knowledge of USFDA requirements and inspection expectations will be an added advantage.
G. Analytical & Cross-Functional Collaboration
- Work closely with Analytical/QC teams for process monitoring, impurity evaluation and analytical data interpretation.
- Interpret data from techniques such as HPLC/UPLC, GC, GC-MS/LC-MS, KF, ICP-MS/OES, PSD and thermal/solid-state characterization, as applicable.
- Collaborate effectively with Manufacturing, Analytical/QC, QA, Engineering, EHS, Supply Chain, Regulatory and external technology partners.
- Act as a technical bridge between process development and commercial manufacturing.
3. Technical & Behavioural Competencies:
Technical
- Strong synthetic organic chemistry and reaction mechanism understanding.
- Hands-on experience in API/process development and optimization.
- Strong understanding of scale-up and manufacturing processes.
- Knowledge of impurity chemistry and process analytical data.
- Working knowledge of DoE/statistical analysis and process risk assessment.
- Understanding of flow chemistry and continuous manufacturing.
- Knowledge of GMP and pharmaceutical regulatory expectations.
- Strong scientific documentation and technical report-writing skills.
- Experience with data analytics/statistical tools such as JMP, Minitab, SIMCA or equivalent is desirable.
Behavioural
- Strong scientific problem-solving and analytical thinking.
- Ability to independently plan and execute experiments.
- Ownership and accountability for assigned projects.
- Effective communication and cross-functional collaboration.
- Ability to influence and present technical recommendations.
- Safety-first and quality-focused mindset.
- Curiosity and willingness to adopt new technologies.
4. Expected Level of Responsibility:
The incumbent is expected to progressively demonstrate:
- Independent ownership of assigned process-development projects.
- Ability to identify technical risks and develop mitigation strategies.
- Ability to lead process optimization and troubleshooting activities.
- Ability to provide scientifically sound recommendations to project teams.
- Ability to mentor junior scientists and share technical knowledge.
- Contribution to process intensification, flow chemistry, continuous manufacturing and digital/data-driven MSAT initiatives.
Readiness for cGMP Environment:
Practical exposure to QC and 5S initiatives demonstrate well-versed in GMP-compliant practices, documentation, and safety protocols. Knowledge of USFDA requirements will be considered as added advantage.
Future Growth Potential:
Participation in innovative areas such as flow chemistry and continuous manufacturing initiatives involving analytical support for new technologies.
