Associate Scientific Director, Small Molecule In Vitro Pharmacology (IVP) / 主席研究員

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Job Description

• Leads planning and implementation of in vitro studies to identify and characterize hit/lead molecules for SAR and subsequent in vivo pharmacology studies.

• Serves as an IVP scientific lead in Japan to establish sustainable in vitro platform and its operational framework in the lab closely working with relevant functions/divisions.

• Works as a global IVP leadership team member to improve probability of success of small molecule asset generation by developing and implementing efficient in vitro screening cascade.

• Responsible for the generation of novel in vitro assays to support small molecule projects across therapeutic areas.

• Responsible for quality of in vitro pharmacology data and assay performance.

• Manages in vitro assay data pertaining to synthetic compounds and small molecule libraries

• Works with external vendors to manage any in vitro pharmacology screening work conducted at CROs

ACCOUNTABILITIES:

• Identifies bottlenecks of small molecule programs, and develops strategic plans and methodology for in vitro studies to address key challenges

• Participates in program teams as a representative of IVP and lead scientific discussion on screening methods and cascade

• Develops in vitro assays and executes planned studies internally and/or externally (lead optimization support, screening for new chemotype generation, mechanistic analysis on molecular biology, primary/secondary/counter/confirmatory assay development and implementation, etc)

• Organizes and manages committees for in vitro assay data management pertaining to synthetic compounds and small molecule libraries to effectively leverage internal databases achieving global harmonization

• Evaluates necessity of capital investment for in vitro platform in Takeda Shonan site

• Evaluates CROs for relevant services and promote their effective use

• Develops talents so that internal IVP function can sustainably grow keeping up with cutting edge new technologies

CORE ELEMENTS RELATED TO THIS ROLE:  

• Provides program team with deep scientific insights from molecular biology perspective

• Develops internal capability striking balance between insourcing and outsourcing

• Pursues efficiency proactively introducing automation technologies

DIMENSIONS AND ASPECTS:

Technical/Functional (Line) Expertise

• Being up to date on latest pharmacology assays and data analysis

• Has knowledge to utilize compound and assay databases

• Miniaturization of assays in order to increase assay bandwidth

• Demonstrates broad technical program knowledge

• Acts as the recognized scientific resource on an aspect of a program

• Demonstrates effective project management skills

Leadership Exerts strong leadership to elevate internal scientific level of molecular biology globally

• Posesses tenacious mind to achieve critical goals of the organization

• Plays a pivotal role in establishing one global IVP team in close collaboration with members in other sites

Decision-making and Autonomy

• Plays a pivotal role in IVP lab operation in Takeda Shonan site

• Judgement of ideal balance of internal and external resource allocation for in vitro studies

Interaction

• Interacts with broad range of stakeholders internally (e.g. Drug Discovery Unit, DMPK, Safety) and externally (CROs)

• Frequently communicates with members based in Boston site

Innovation

• Maintains open mindset to adopt new innovative technologies/frameworks to achieve best practice

• Not stick to historical standard

• Strives to identify/generate differentiated molecules from molecular biology standpoint

Complexity

• Needs to work with diverse people from technicians to area-specific experts in interdisciplinary projects

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

• PhD degree in a scientific discipline with 5+ years experience , or

• MS with 7+ years experience, or

• BS with 9+ years experience in in vitro assay development and/or molecular biology

• Familiarized with both cell-based and cell-free assays including biochemical assays (e.g. binding and enzymatic assays) to evaluate small molecules

• Preferably, with experience and knowledge for biophysical assays

• Posses sufficient knowlege on assay material preparation such as procedures of cloning, genetic modifications of cell lines, protein expression and purification, etc.

• Experiece and/or familiarity with molecular screening

• Broad familiarity with overall process of preclinical research

• Good command of Excel based data analysis

• Good communication skill to establish good relationship with global members

Takeda Compensation and Benefits Summary:

• Allowances: Commutation, Housing, Overtime Work etc.

• Salary Increase: Annually, Bonus Payment: Twice a year

• Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, (Narita) 8:30-17:15, Research Site (Kanagawa) 9:00-17:45

• Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)

• Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave.

• Flexible Work Styles: Flextime, Telework

• Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc.

Important Notice concerning working conditions:

• It is possible the job scope may change at the company’s discretion.

• It is possible the department and workplace may change at the company’s discretion.

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