Research Senior Associate, Cell Therapy

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Job Description

Pursuant to Section 20 C.F.R. 656.10, you are hereby notified that an application for Alien Employment Certification will be filed by Takeda Development Center Americas, Inc. for the following job opportunity:

JOB LOCATION: Cambridge, MA

POSITION: Research Senior Associate, Cell Therapy

POSITION DESCRIPTION: Takeda Development Center Americas, Inc. is seeking a Research Senior Associate, Cell Therapy with the following duties: Plan and independently execute in vitro experiments to deliver data for cell therapy discovery platforms; Scope of experiments include production of engineered human and mouse T cells, proof-of-concept studies, target identification and selection, lead optimization, and functional assessments; Adapt or develop, evaluate, and troubleshoot in vitro and ex vivo experimental techniques; Create, compile, analyze, and record experimental data; Review, interpret, and present results internally in research team and cross-departmental meetings; Serve as a technical resource in the laboratory for other employees by demonstrating techniques and preparing study protocols and internal technical transfer documentation; Utilize scientific literature to increase knowledge base and implement improvements; Assist with development of project strategy; up to 20% remote work allowed.

REQUIREMENTS: Master’s degree in Biotechnology, Immunology, Molecular Biology, Biomedical Engineering or related scientific field or related field plus 1 year of related experience. Prior experience must include: Culture primary T cells, including their activation, expansion, and cryopreservation, to develop an engineered cell therapy product using viral (retroviral or lentiviral) transduction methods; Characterize T cells and other leukocytes using multi-color flow cytometry for immunophenotyping, immunofluorescence staining and microscopy to detect and visualize molecular markers, and ELISA and multiplexed luminescent readouts such as MSD to measure cytokines and other secreted proteins; Develop and execute in vitro co-culture experiments to assess the functions of T cells and other leukocytes, assay proliferation and cytotoxic killing of target cells, generate 3D spheroid models from tumor cell lines, time-lapse imaging experiments using Incucyte, and incorporate automation in the workflow of experiments; Process biosamples - such as human blood, human tumors, mouse blood, or mouse organs, for downstream ex vivo analysis or T cell enrichment; analyze and present experimental data using scientific software such as Flowjo and GraphPad Prism, maintain detailed experimental records in electronic lab notebooks, present and communicate experimental results to project team members.

Full time. $86,500.00 - $148,300.00 per year. Competitive compensation and benefits.

Qualified applicants can apply at https://jobs.takeda.com. Please reference job #R0153069. EOE

Any individual may provide documentary evidence bearing on this application, with information on available workers and information on wages and working conditions, to the Certifying Officer, U.S. Department of Labor, Employment and Training Administration, Office of Foreign Labor Certification, 200 Constitution Avenue, NW, Room N-5311, Washington, DC 20210.

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