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Sr. Manager, In Silico First Program & Strategy Management

Boston, Massachusetts
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  • Job Level: Senior
  • Travel: 5-10%

The Pharmaceutical Sciences (Pharm Sci) organization is an integral part of global R&D at Takeda, translating science into therapeutic products for patients. When you join Pharm Sci, you become part of a team dedicated to bringing our products to life for our patients through innovation, dedication and talent while minimizing environmental impact.

We work as a member of Takeda’s Global Program Team (GPT) and take full ownership of Chemistry, Manufacturing & Control (CMC) activities — driving product development from bench to bedside.

The Pharm Sci team focuses on executing and enhancing business processes and partnering with key stakeholders and industry leaders to boldly deliver an increasingly complex portfolio. Always looking through a sustainability lens to protect our planet, we are embracing new ways of working, excelling in our data and digital transformation, building differentiated capabilities (CMC Acceleration), delivering innovative medical devices, and advancing an inclusive, innovative culture.

It is an exciting time to be in Pharm Sci. Join our journey and change the lives of patients!

Job ID R0170037 Date posted 12/12/2025 Location Boston, Massachusetts

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Pursuant to Section 20 C.F.R. 656.10, you are hereby notified that an application for Alien Employment Certification will be filed by Takeda Development Center Americas, Inc. for the following job opportunity:

JOB LOCATION: Cambridge, MA

POSITION: Sr. Manager, In Silico First Program & Strategy Management

POSITION DESCRIPTION: Takeda Development Center Americas, Inc. is seeking a Sr. Manager, In Silico First Program & Strategy Management with the following duties: independently manage roadmaps and strategic plans to advance the ISF program, in alignment with company goals and objectives; oversee day-to-day operations of the initiative, ensuring smooth execution and timely delivery of projects; collaborate with and influence stakeholders, including the PharmSci Capability Owners in the global suites as well as the local functional teams to ensure initiative alignment and scalability across the global framework; foster cross-functional collaboration to drive the adoption of innovative methodologies while maintaining regulatory compliance where only recent guidance is available and is evolving; establish and monitor performance metrics to gauge the success and ROI of the ISF roadmap and ensure alignment with strategic business goals; lead resource planning, budget management, and timelines across Pharm Sci functional areas; manage with close support external vendor partnerships to enhance execution & scalability of PSST initiatives; support Change Management efforts to facilitate smooth transitions to new processes & technologies, ensuring stakeholder engagement & minimizing disruptions; drive strategic communication efforts to ensure clear understanding and support of the In Silico First paradigm by and across the organization; provide technical expertise in in silico model development, ensuring the application of best practices and cutting-edge methodologies; serve as an embedded in silico Subject Matter expert in select lighthouse projects; drive the development and validation of computational models, leveraging deep expertise in silico approaches; ensure the integration of in silico models with experimental data and workflows to enhance predictive accuracy and reliability and ensure increased productivity. Up to 10% international travel required to attend business meetings, subject matter consultation, and visit local sites for program oversight. Up to 75% remote work permitted.

REQUIREMENTS: Ph.D. in Pharmacy and Biomedical Sciences or related field, plus 2 years of related experience. Prior experience must include: contribute to the creating of global strategic roadmaps and frameworks (such as the Pharm Sci Digital Strategy and R&D Integrated Digital Strategy, while effectively managing project timelines and deliverables, planning and coordinating projects with departmental, functional, and external stakeholders; lead change management strategy for In Silico First and Aedifica Fortis, managing close collaboration with external vendors to enhance execution of these strategies; oversee day-to-day operations of the Aedifica fortis portfolio for Pharm Sci, ensuring strategic alignment, successful execution and timely delivery of projects; drive technical projects for the In Silico First initiative, which integrates in silico models with experimental data and workflows to enhance predictive accuracy and reliability to ensure increased productivity and reduced resource and time consumption.

Full time. $137,000 to $234,800 per year.

Qualified applicants can apply at https://jobs.takeda.com. Please reference job #R0170037. EOE

Any individual may provide documentary evidence bearing on this application, with information on available workers and information on wages and working conditions, to the Certifying Officer, U.S. Department of Labor, Employment and Training Administration, Office of Foreign Labor Certification, 200 Constitution Avenue, NW, Room N-5311, Washington, DC 20210.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time
Apply Now

Where you fit in

Our teams are experienced in medicinal chemistry, multi-step synthesis, multimodal genetics, genomics datasets, pharmacokinetics and more. So wherever your expertise and passion lie, your work will have tangible outcomes, advancing an innovative pipeline that serves unmet needs.

We're delving deeper than ever inside the human body and its microbiome, implementing innovative approaches to deliver high-quality products that treat a range of illnesses, including IBD and cancer.

In our diverse, forward-thinking culture, we're constantly embracing new ways of working:

  • Partnering with research teams, GPTs, business development and our commercial partners in GMS/GQ
  • Supporting all stages of pre-clinical and clinical development
  • Providing enabling technologies, including formulation and delivery strategies, analytical expertise and IP
  • Developing processes to manufacture high-quality Clinical Trial Material and other
  • Focusing on broad therapeutic areas on multiple device platforms: Advanced Delivery Devices, Home & Point-Of-Care Diagnostics, Software & Connectivity for eHealth devices and state-of-the-art Medical Devices & Combination Products

On our team in Pharmaceutical Sciences, you’ll notice a big difference in your own life, too. You’ll be supported to develop your career. You'll connect with brilliant minds and be recognized for your accomplishments. Your curiosity, skills and dedication will have a place and a purpose. So even when you’re exploring the smallest of details, your world will be bigger than ever.

  • Perform cell processing operations

  • Support clean room activities

  • Ensure equipment maintenance

  • Support investigations in deviations

Along with incredibly passionate colleagues, there’s a clear commitment to invest in the best facilities and the right equipment needed to successfully perform world-class science.
christina alves headshot

Christina Alves - Head of Biotherapeutics Process Development

Within Takeda, there’s a lot of room for disruption and challenging how things have been done before.
headshot of briana rawson

Briana Rawson - Lead, Human Factors Engineer

I love that I get to connect smaller, newer ventures with Takeda’s reputation and resources so that we can develop innovative ways of diagnosing and managing the conditions of patients with unmet needs.
headshot of rachel whitaker

Rachel Whitaker - Principal Engineer, Diagnostic Devices

The heart of our work

Leading with innovation

Our pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

Learn more

What we believe in

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

  • Integrity

  • Fairness

  • Honesty

  • Perseverance

Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.
  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.
  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
  • Great Place to Work

    Recognized for our culture and ways of working, we’re proud to be Certified as a Great Place to Work® in 25 countries and regions.
  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.
  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

We're Steadfast In Our Commitment to Four Key Imperatives

Patient


Responsibly translate science into highly innovative medicines and accelerate access to improve lives worldwide.

People


Create an exceptional people experience.

Planet


Protect our planet.

Data & Digital


Transform Takeda into the most trusted, data-driven, outcomes-based biopharmaceutical company.

Exterior of Takeda Building

About our location

Boston, Massachusetts


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