Job Posting

Senior Research Associate, HTP Protein Production

Boston, Massachusetts

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Job Level: Senior
Travel: Minimal (if any)

At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.

Job ID R0147866 Date posted 04/08/2025 Location Boston, Massachusetts

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Job Description

Objective / Purpose:

The role within the High-Throughput Protein Production Team under the Global Biologics Group is centered around advancing early therapeutic discovery using high-throughput techniques. This involves cloning, mammalian transfection, purification, and optimization utilizing the latest automation technologies. The position demands involvement in designing and executing experiments, data analysis, and strategy development for protein production and automation. Additionally, the role includes contributing to matrix project teams and facilitating collaboration with various therapeutic groups, requiring effective communication and adaptability in fast-paced environments.

Accountabilities

Independently perform high throughput production of proteins in various formats, including antibody-based (mAbs, bispecific, VHHs, Fc-fusion, etc) and alternative formats to discover and advance novel therapeutics.
Perform cloning, plasmid prep, transient expression, and purification of protein constructs using automated liquid handlers (Tecan, Hamilton, Dynamic Devices).
Independently operate, edit, and troubleshoot program scripts for a variety of liquid handling robotic platforms.
Perform mammalian cell culture work, including the maintenance of cell lines.
Perform HTP analytics such as CE-SDS and aSEC.
Evaluate and implement new methods for high throughput protein production.
Perform data analysis and tracking using LIMS systems and maintain detailed ELN
Summarize and communicate results at team meetings and contribute to scientific discussions.
Troubleshoots complex problems and actively participates in innovation and/or optimization of established processes and workflows to ensure delivery on project goals
Assist and share responsibilities on routine lab practices such as managing inventory and maintenance of equipment.

Education & Competencies

MS in a scientific discipline (or equivalent) with 2+ years of relevant experience, or BS with 4+ years of relevant experience
Minimum 2 years of industry experience
Experience with protein production workflow in an industry setting is required
Knowledge and hands-on experience in molecular cloning, protein expression and purification, and protein characterization are required
Previous experience with the operation of laboratory automation is required
Experience with mammalian cell culture, including CHO and HEK cell lines is required
Previous experience in protein analyticals such as aSEC and CE-SDS is highly desirable
Prior experience with LIMS, preferably GeneData Biologics is highly desirable
Experience with molecular biology techniques and software such as SnapGene and Geneious Prime is a plus
Excellent written and verbal communication and organization skills, along with the ability to work in cross-functional settings

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$86,500.00 - $135,960.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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Where you fit in

Our team at Takeda is tackling some of the most challenging problems in drug discovery and development. As the newest member of our Research team, you’ll conduct purposeful, meaningful work on groundbreaking modalities that may lead to breakthrough drugs.

With our deep investment in next-generation technologies, you’ll have the resources and support to do your best work. As a part of our team, you’ll connect with brilliant minds inside and outside of Takeda. We are committed to collaborating with academia and emerging biotech companies to expand our reach and impact in cell therapy, gene therapy and data sciences.

Our team’s wide-ranging expertise includes medicinal chemistry, genomics datasets, immunofluorescence, high content imaging, flow cytometry, transcriptional profiling, multi-step synthesis, multimodal genetics, pharmacokinetics and much more. Whatever area inspires you, your work will support the progression of an innovative, industry-leading discovery pipeline and make an impact that matters to patients and society.

A career in Research at Takeda will give you everything you need to succeed professionally — and make a difference to patients, people and the planet.

Design and carry out experiments
Manage multiple projects
Document data
Mentor other scientists

Along with incredibly passionate colleagues, there’s a clear commitment to invest in the best facilities and the right equipment needed to successfully perform world-class science.

Christina Alves - Head of Biotherapeutics Process Development

Our pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

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What we believe in

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

Integrity
Fairness
Honesty
Perseverance

Working at Takeda

Inclusion
Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.
Collaboration
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Innovation
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Empowerment
Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.