Director of GI/Inflammation and Neuroscience- Biologics In Vitro Pharmacology

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Job Description

Director of GI/Inflammation and Neuroscience-  Biologics In Vitro Pharmacology

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as a Director where you will play a major role in the discovery of novel biologics, contributing to the strategic direction of our GI/Inflammation and Neuroscience research programs.

How you will contribute:

• Strategic Leadership- Provide strategic direction to the GI/Inflammation and Neuroscience discovery project teams, ensuring alignment with company goals and objectives.
• Functional Leadership-
  • Oversee the strategy for functional evaluation and candidate selection of novel GI/ Inflammation and Neuroscience therapeutics. 
  • Lead a team responsible for the design, development and execution of state-of-the-art in vitro pharmacology assays to evaluate the biological activity, potency, efficacy, and mechanism of action of our novel therapeutics, utilizing cutting-edge technologies (e.g., complex cell-based assays, co-culture systems, and 3D organoid models) to measure cellular responses in inflammatory pathways, and neuronal cell signaling.
  • Develop and implement innovative technologies to elevate our in vitro pharmacology capabilities and throughput to enhance translation and increase quality and efficiency.  Stay abreast of the latest scientific advancements and industry trends.
• Program Leadership: Lead the GI/Inflammation and Neuroscience biologics discovery programs with cross-functional discovery teams, driving the programs from lead ID to preclinical development.
• Collaboration: Build strong internal and external collaborations, foster alignment with our key stakeholders. Collaborate closely with interdisciplinary research teams in a matrix format, to advance discovery programs.
• Mentoring: Mentor and develop team members, fostering a culture of innovation, collaboration, and scientific excellence.

Minimum Requirements/Qualifications:

• PhD degree in immunology or a related scientific discipline with 10+ years’ experience.
• Minimum of 10 years of experience in GI/Inflammation and Neuroscience research, with at least 7 years industry experience in pharma, biotech with a track record of leading GI/inflammation and Neuroscience discovery projects, specifically in Autoimmune and inflammatory diseases.
• Minimum of 7 years of management experience.
• Expertise in biologics drug discovery and development processes, including hit identification, lead optimization, candidate selection, and preclinical development.
• Proven track record of leading successful in vitro pharmacology efforts in the field of GI/Inflammation and Neuroscience, including assay development and validation, functional screening, and mechanism of action studies.
• Strong technical proficiency in a wide range of in vitro pharmacology techniques and assay formats, including complex cell-based phenotypic assays, immune cell-based assays, co-culture systems, inflammation-based assays, neuronal models and GI organoid systems, flow cytometry, and high content imaging.
• Excellent leadership, communication, and interpersonal skills, with the ability to lead a team and projects and collaborate effectively across disciplines, demonstrate enterprise leadership with an ability to influence without authority.
• Knowledge of regulatory requirements and guidelines for drug discovery and development

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

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Job Exempt