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Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as a Director where you will evaluate the biological activity of the potential therapeutics candidates generated in global biologics and select the best candidates for further preclinical and clinical development. You will also lead a team responsible for designing and implementing vitro pharmacological assays, utilizing state-of-the-art technologies and methodologies, leading the discovery of novel biologics, and contributing to the strategic direction of our Immunotherapy and Immuno-oncology research programs. As part of the In Vitro Pharmacology team, you will report to the Head of the team and work with the Global Biologics organization.

How you will contribute:

• Strategic Leadership: Provide strategic direction and leadership for the Immunotherapy and Immuno-oncology in vitro pharmacology team, ensuring alignment with company goals and objectives. Develop and implement innovative strategies to support the discovery and development of novel therapies.
• Functional Leadership: Lead the design, development, optimization and execution of high-quality in vitro pharmacology assays to evaluate the activity, mechanism of action, and efficacy of Immunotherapy and Immuno-oncology therapeutics. Utilize cutting-edge technologies and methodologies to assess immune cell function, immune checkpoint pathways, and tumor-immune interactions. Develop and implement strategies to enhance the in vitro pharmacology capabilities and throughput. Stay abreast of the latest scientific advancements and industry trends.
• Program Leadership: Lead the Immunotherapy and Immuno-oncology biologics discovery programs with cross-functional teams, driving the programs from lead ID to preclinical development.
• Candidates Screening and Profiling: Oversee the screening and profiling of biologic drug candidates in relevant in vitro models including immune cell-based assays, co-culture systems, and 3D organoid models. Evaluate candidate efficacy, potency and selectivity, to support lead optimization and candidate selection.
• Mechanism of Action Studies: Investigate the molecular mechanisms underlying the activity of therapeutic candidates using in vitro pharmacology approaches. Characterize interactions with immune targets, signaling pathways, and immune cell subsets to elucidate therapeutic mechanisms and inform drug development strategies.
• Cross-Functional Collaboration: Collaborate closely with interdisciplinary discovery teams in a matrix format, including biologics engineering, biologics production, analytics, translational scientists, and preclinical development teams to advance discovery programs. Communicate results effectively and contribute to project team meetings, scientific discussions, and project planning activities.
• Mentoring: Mentor and develop junior scientists, fostering a culture of innovation, collaboration, and scientific excellence.

Minimum Requirements/Qualifications:

• PhD degree in immunology, cancer biology, or a related scientific discipline with 10+ years experience , or MS with 16+ years experience, or BS with 18+ years experience.
• Minimum of 10 years of experience in Immunotherapy/immuno-oncology research, with a focus on immune cell biology, immune checkpoints, and tumor-immune interactions.
• Minimum of 7 years of management experience.
• Expertise in drug discovery and development processes, including hit identification, lead optimization, candidate selection, and preclinical development.
• Proven track record of leading successful in vitro pharmacology efforts in the field of immunotherapy/immuno-oncology , including assay development and validation, candidates screening, and mechanism of action studies.
• Strong technical proficiency in a wide range of in vitro pharmacology techniques and assay formats.
• Excellent leadership, communication, and interpersonal skills, with the ability to lead a team and projects and collaborate effectively across disciplines, demonstrate enterprise leadership with an ability to influence without authority.
• Knowledge of regulatory requirements and guidelines for drug discovery and development

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

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Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

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