Skip to main content

Research Scientist, Antibody Discovery & Engineering, In Vivo Based Methods

Cambridge, Massachusetts
Apply Now
  • Job Level: Senior
  • Travel: Minimal (if any)

At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.

Job ID R0125738 Date posted 06/27/2024 Location Cambridge, Massachusetts

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as a Research Scientist where you will utilize state-of-the-art discovery technology and creating novel treatments to make a large impact on patients’ lives in the fields of Oncology, Gastroenterology and Neuroscience. You will contribute to swift and efficient discovery of biologic therapeutics using in vivo based approaches is the core remit and have a deep scientific engagement and involvement in programs; helping to define the best path forward based on the therapeutic needs, designing immunization strategies, performing immunizations/animal handling and tissue harvest, and conducting HT antibody discovery using technologies using single B cell cloning coupled with NGS. You will also necessitate familiarity with associated screening workflows and data analysis in addition to possessing a sound knowledge of B cell biology, humoral immunity and immunoglobulin genetics and familiarity with basic building block biologics IgG, Fab, sdAb as well as design and optimize lead candidates using display-based technologies (yeast, phage) may also be part of the role. As part of the Biotherapeutic Engineering team, you will report to Senior Director of the team and interface very closely with cross functional project team members to make data driven decisions with impact on pipeline is vital. Here, you will bring strong experience in antibody and biologic discovery to the team and recognize, and streamline for the most efficient ways of working is a high priority in this role, and the role requires tremendous drive, motivation to deliver (and beat) team and program goals, while also pushing the boundaries to enhance discovery and optimization. Working and networking excellently within the team is critical for best performance and team engagement.

How you will contribute:

  • Draw on expertise from in vivo based discovery platforms to provide thoughtful guidance on strategies towards candidate profiles for differing target types, including discovery and optimization/ engineering approaches to enhance properties.
  • Design and execute immunization strategies including guidance and definition of best immunogen, adjuvant, and immunization routes, conducting immunizations using transgenic mice, while overseeing strategies with other species such as llama.
  • Execute hands-on wide array of immunization methodologies autonomously, encompassing protein, cell, and DNA materials, utilizing diverse immunization routes and/or gene gun strategies proficiently.
  • Perform animal tissue harvest, B cell separation, and refined enrichment techniques for antigen-specific antibody screening that will include plasma and memory B cell sorting (Beacon and FACS based methods). Perform single-cell RT-PCR, PCR, molecular cloning, and BCR sequence analysis to harvest variable antibody regions for expression and/or repertoire cloning into display platforms, with associated analysis and management of data. Collaborate effectively with high-throughput mammalian expression teams for downstream expression and purification tasks.
  • Work closely with NGS discovery team incorporating appropriate and thoughtful analysis throughout the discovery process.
  • Prepare and present comprehensive technical or project reports and formal presentations and posters to a broad range of internal/external audiences.
  • Interface with cross functional teams, including members from the broader biologics team, disease areas, DMPK and DSRE.
  • Remain aware of the competitive landscape in the field through literature .
  • Team-centric mindset is key.
  • Significantly contribute to the strategies for biologics discovery and engineering of both discovery and final therapeutic modalities.
  • Set high standards for effectiveness of execution, efficiency and rigor of thought.

Minimum Requirements/Qualifications:

  • PhD degree in a scientific discipline (or equivalent), or MS with 6+ years relevant experience, or BS with 8+ years relevant experience.
  • Demonstrates theoretical knowledge of discipline in the field of in vivo antibody based antibody discovery.
  • Keeps current with emerging trends in discipline

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

#LI-SGM

#LI-Onsite

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

USA - MA - Cambridge

U.S. Base Salary Range:

108,500.00 - 170,500.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

USA - MA - Cambridge

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes
Apply Now

Where you fit in

Our team at Takeda is tackling some of the most challenging problems in drug discovery and development. As the newest member of our Research team, you’ll conduct purposeful, meaningful work on groundbreaking modalities that may lead to breakthrough drugs.

With our deep investment in next-generation technologies, you’ll have the resources and support to do your best work. As a part of our team, you’ll connect with brilliant minds inside and outside of Takeda. We are committed to collaborating with academia and emerging biotech companies to expand our reach and impact in cell therapy, gene therapy and data sciences.

Our team’s wide-ranging expertise includes medicinal chemistry, genomics datasets, immunofluorescence, high content imaging, flow cytometry, transcriptional profiling, multi-step synthesis, multimodal genetics, pharmacokinetics and much more. Whatever area inspires you, your work will support the progression of an innovative, industry-leading discovery pipeline and make an impact that matters to patients and society.

A career in Research at Takeda will give you everything you need to succeed professionally — and make a difference to patients, people and the planet.

  • Design and carry out experiments

  • Manage multiple projects

  • Document data

  • Mentor other scientists

Along with incredibly passionate colleagues, there’s a clear commitment to invest in the best facilities and the right equipment needed to successfully perform world-class science.

Christina Alves - Head of Biotherapeutics Process Development

Our pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

Learn more

What we believe in

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

  • Integrity

  • Fairness

  • Honesty

  • Perseverance

Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.
  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.
  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 17 companies to receive Top Global Employer® status for 2024.
  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.
  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

We're Steadfast In Our Commitment to Four Key Imperatives

Patient


Responsibly translate science into highly innovative medicines and accelerate access to improve lives worldwide.

People


Create an exceptional people experience.

Planet


Protect our planet.

Data & Digital


Transform Takeda into the most trusted, data-driven, outcomes-based biopharmaceutical company.

Exterior of Takeda Building

About our location

Cambridge, Massachusetts


View Map of Cambridge, Massachusetts

Join our talent community

Get customized job alerts sent right to your inbox. Plus, get the latest in company news and other important resources by signing up for our talent community.

Learn about job updates