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Head of ADME Sciences

Multiple Locations
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  • Job Level: Senior
  • Travel: Minimal (if any)

At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.

Job ID R0121830 Date posted 04/26/2024 Location Multiple Locations

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Job Description

Locations:

  • Cambridge, MA or
  • San Diego, CA or
  • Japan - Shonan

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Objective / Purpose:

  • As the Head of ADME Science, you will be the leader of the ADME Sciences function within the global DMPK&M department and is a global position. You will lead a group of scientists to provide in vitro mechanistic ADME, biotransformation and biodistribution support to Oncology, Gastrointestinal and Neuroscience Drug Discovery Units for developing diverse modality therapeutics and report to the Global Head DMPK.

  • You will prepare the ADME Sciences functional strategy, lead and organize all activities in-house or through CROs to support projects.

  • You will have an impressive record of accomplishments and publications in the ADME Sciences and related areas and have knowledge and troubleshooting in in vitro mechanistic ADME, biotransformation, and biodistribution supporting drug discovery and development, and regulatory compliance of ADME sciences studies. You should understand the requirements of ADME data for PBPK modeling, and an understanding of how PBPK impacts research and development.

  • You must have excellent communication, interpersonal skills, a proven track record of leading, managing, developing, and inspiring scientists.

Accountabilities:

  • You will be the subfunction leader and lead in vitro mechanistic ADME, biotransformation, and biodistribution scientists to provide ADME Sciences support with close interaction with development projects to work with GPT & DDU project leaders, DMPK&M and DSRE leaders and representatives, PTS Operations, Reagent Sourcing, BBST, CRO reps, and other relevant study personnel. 
  • Communicate with the internal and external stakeholders regarding the ADME science project support strategies, assay needs, study progress updates, and ADME Sciences deliverables.  Plan with in vitro mechanistic ADME, biotransformation, and biodistribution lead scientists on study activities to meet the established timelines and execute global strategy.  Prioritize and re-prioritize activities to deal with urgent and important requests.
  • Serve as the ultimate ADME Sciences scientific leader to guide all the activities of a diverse team of scientists and sets scientific strategy for the ADME Sciences team.  Anticipate and mitigate potential technical issues and bottlenecks for in-house activities. 
  • Provide penultimate scientific oversight for outsourced work on method transfer/adoption, development/re-development, sample analysis, and data delivery.
  • Actively follow and set the trends of the industry and seek novel solutions to meet ADME Science’s needs.  Develop, oversee, and adopt new technologies for addressing the new scientific challenges in project support.  Mentor team leaders and scientists as necessary.
  • Proactively identify opportunities for self or group members to update professional skills through training or participating in conferences.  Contribute to external presentations and publications.

Education & Competencies (Technical and Behavioral):

  • PhD degree in a DMPK and/Modeling scientific discipline with 15+ years’ experience, or
  • MS with 21+ years’ experience, or
  • BS with 23+ years’ experience
  • 9 years of Industry experience required
  • 9 years of managerial experience required

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$169,400.00 - $266,200.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

JPN - Kanagawa - iPark, San Diego, CA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time
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Glassdoor Reviews and Company Rating

Where you fit in

Our team at Takeda is tackling some of the most challenging problems in drug discovery and development. As the newest member of our Research team, you’ll conduct purposeful, meaningful work on groundbreaking modalities that may lead to breakthrough drugs.

With our deep investment in next-generation technologies, you’ll have the resources and support to do your best work. As a part of our team, you’ll connect with brilliant minds inside and outside of Takeda. We are committed to collaborating with academia and emerging biotech companies to expand our reach and impact in cell therapy, gene therapy and data sciences.

Our team’s wide-ranging expertise includes medicinal chemistry, genomics datasets, immunofluorescence, high content imaging, flow cytometry, transcriptional profiling, multi-step synthesis, multimodal genetics, pharmacokinetics and much more. Whatever area inspires you, your work will support the progression of an innovative, industry-leading discovery pipeline and make an impact that matters to patients and society.

A career in Research at Takeda will give you everything you need to succeed professionally — and make a difference to patients, people and the planet.

  • Design and carry out experiments

  • Manage multiple projects

  • Document data

  • Mentor other scientists

Along with incredibly passionate colleagues, there’s a clear commitment to invest in the best facilities and the right equipment needed to successfully perform world-class science.

Christina Alves - Head of Biotherapeutics Process Development

I feel especially lucky to be able to work with colleagues across the industry to meet a unified goal.Takeda is paving the way for how research will be conducted in the future.

Daniel Scheibe - Senior Manager Operations, Systems Engineering, Drug Discovery Sciences

Our pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

Learn more

What we believe in

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

  • Integrity

  • Fairness

  • Honesty

  • Perseverance

Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.

  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.

  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.

  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 17 companies to receive Top Global Employer® status for 2024.

  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.

  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

We're Steadfast In Our Commitment to Four Key Imperatives

Patient


Responsibly translate science into highly innovative medicines and accelerate access to improve lives worldwide.

People


Create an exceptional people experience.

Planet


Protect our planet.

Data & Digital


Transform Takeda into the most trusted, data-driven, outcomes-based biopharmaceutical company.

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