Research Investigator

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Job Description

Pursuant to Section 20 C.F.R. 656.10, you are hereby notified that an application for Alien Employment Certification will be filed by Takeda Development Center Americas, Inc. for the following job opportunity:

JOB LOCATION: Cambridge, MA

POSITION: Research Investigator

POSITION DESCRIPTION: Takeda Development Center Americas, Inc. is seeking a Research Investigator with the following duties: Lead efforts to design and develop analytical methods for the characterization of chimeric antigen receptor cells such as: immunophenotyping functionality and high throughput assays; Contribute strategic planning of activities, including prioritizing experiments, timelines effectively to meet project milestones and deliverables; Validation and Optimization: Revise and enhance the parameters within existing methodologies to align with the specifications of designed cells, including adjustments to co-culture duration, selection of appropriate fluorophores for cell staining, and optimization of dilution ratios to ensure compatibility within the operational scope; Exercise independent judgement in selecting most appropriate methods, coordinating efforts, evaluating criteria for obtaining results; Analyze experimental data, interpret results, and independently draw conclusions to support product development, formulation, and processes; Summarize and present data within department and occasionally to broader audience; Contribute to technological transfer of experimental procedures/data internally and external stakeholders as appropriate to integrate subject matter expertise into various projects, initiatives; Prepare comprehensive reports, protocols, and documentation for analytical methods, validation studies, and experimental findings, maintaining accurate records in compliance with regulatory standards; up to 5% domestic travel required.

REQUIREMENTS: Master of Science degree in Chemical Engineering or related field plus 2 years of related experience. Prior Experience must include: Perform High throughput immunophenotyping assay characterizes the drug product; Perform data analysis using FlowJo, MS Office and GraphPad Prism to know phenotypic composition of cell product; Immune cell handling, including cell isolation using Ficoll-Paque density gradient centrifugation, cell culture; Functional assays like proliferation and activation assays; Perform functional assays like ELISA to characterize cell therapy product; Routinely test solubility and stability of compounds using UPLC, HPLC and analyze using Chromeleon; Characterize in-process and drug products using Multi color flow cytometry to know the cell composition; Prepared sensor substrate by selecting suitable material like silicon and functionalized it to promote interaction with MIPs; Prepare Molecular Imprinted Polymer solution by dissolving the polymer in suitable solvent.

Full time. $96,600.00 - $165,600.00 per year.  Competitive compensation and benefits.

Qualified applicants can apply at https://jobs.takeda.com. Please reference job #R0138582. EOE

Any individual may provide documentary evidence bearing on this application, with information on available workers and information on wages and working conditions, to the Certifying Officer, U.S. Department of Labor, Employment and Training Administration, Office of Foreign Labor Certification, 200 Constitution Avenue, NW, Room N-5311, Washington, DC 20210.

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