Research Associate, Cell Line Development

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Job Description

OBJECTIVE:

Responsible for supporting the cell line development (CLD) team through participation in transfection, stable selection, cloning, expansion, characterization of mammalian cell lines for clinical and commercial production, as well as automation, data processing and digitalization. This position will perform laboratory experiments using a variety of CLD and cell culture technologies including single cell cloning/clone picking, cell imaging, liquid handling automation and Octet/ELISA-based recombinant protein quantification. The candidate will need strong organizational skills and experience with a variety of data and digital tools for review and interpretation of data and its use in models to improve CLD outcomes. . Programming skills with Python, R, etc. is a plus.  This position will be expected to conduct experiments with supervision, document experimental steps in an electronic laboratory notebook, and draft support documentation.

ACCOUNTABILITIES:

• Familiar with molecular biology and cell culture techniques, previous CHO cell line development experience is appreciated

• Familiar with general laboratory procedures and aseptic technique.

• Contributes directly to project work which may include multiple projects within functional area and presents data in group meetings

• Identifies technical issues and implements solutions under supervision.

• Support technology development projects as well as cell line development for pipeline molecules under supervision.

• Prepares experimental protocols and keeps good records of experiments

• Coordinates within department as well as cross functionally with peers on projects.

• Experience with data and digital applications and programing language will be a plus

• Experience with automation, FACS, ddPCR and Next-Gen Sequencing will be a plus

EDUCATION, EXPERIENCE AND SKILLS:

• Bachelor’s degree in biochemistry, molecular biology, biotechnology, or related pharmaceutical science; 1+ years of biotechnology/biopharmaceutical industry experience, preferably in cell line development

• Master’s degree in biochemistry, molecular biology, biotechnology, or related pharmaceutical science

Knowledge and Skills:

• Learning Skills - Able to learn different procedures under supervision or from protocols, has attention to details to identify and solve problems

• Teamwork - Ability to work within department groups/team.

• Communication Skills - Expresses oneself clearly and concisely within function; documents issues and/or concerns concisely with colleagues; timely and effectively communicates issues to supervisor

• Organization - Exercises good time management skills

• Technical - Proficient in use of applicable lab equipment and operations

Physical Demands:

Cell culture technique does involve some repetitive motion.

LINE FUNCTION SPECIFIC QUALIFICATIONS:

Biologics – Upstream Process Development: Cell line development:

• Sound knowledge of cell culture principles, experience in aseptic techniques required

• Experience in CLD technologies including culture of mammalian cells, single cell cloning (sorting/clone picking), clonality assessment, and clone screening highly desirable

• Experience in molecular biology methods including subcloning, northern blot, RT-qPCR/ddPCR and Octet/ELISA-based recombinant protein quantification is desirable

Takeda Compensation and Benefits Summary

For Location:

Boston, MA

U.S. Hourly Wage Range:

$26.92 - $42.31

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

No

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