Therapeutic Area Manager Genetic Disease

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Job Description

Therapeutic Area Manager Genetic Disease

OBJECTIVES/PURPOSE:

The role is pivotal in driving Takeda Kazakhstan’s Genetic Diseases portfolio by delivering expert scientific leadership across all product life cycle stages, including Replagal, Elaprase, and Vpriv. As the primary medical and clinical interface, the position ensures high-quality interpretation of complex data, supports localization of global strategies, and strengthens scientific networks at both country and cross-border levels. Leveraging AI technologies, the role enhances insight generation, medical content development, and omnichannel engagement to support healthcare system reforms and digital transformation in rare disease management. This position is critical to sustaining diagnostic and treatment rates in Fabry and MPS II, and to maintaining Takeda’s leadership in the evolving orphan disease landscape.

ACCOUNTABILITIES: 

Provide up-to-date scientific expertise in the therapeutic area (TA) of the responsibilities including marketed, registered, launch, pre-launch, and pipe-line products of Genetic Diseases portfolio in Takeda Kazakhstan including, but not limited with Replagal, Elaprase, and Vpriv. Continuously maintain knowledge in the (TA), attend internal trainings and monitor external scientific resources using AI when appropriate Active participant of internal and external product scientific network, main point of contact for scientific communication internally and externally Generate insights, analyze insights at country level and develop and implement appropriate action plan Provide input in the country brands strategy and active member of brand team

Implement localization of Global Medical strategy under supervision of medical director Responsible for the implementation of in-country medical tactics within the budget approved by Medical Director Develop, approve, produce, and ensure quality of medical materials using traditional methods and AI technologies Take part in the implementation of omnichannel Train filed medical colleagues, take part in organization growth  Train commercial colleagues based on the request Responsible for medical review and approval of promotional materials in TA of receptibilities Provides expertise during development of local labeling documents Role model of integrity and compliance

CORE ELEMENTS RELATED TO THIS ROLE: 

Strategic Importance: The GD (Genetic  Disease) Therapeutic Area Manager (TAM) is essential to Takeda Kazakhstan’s success, as Replagal and Elaprase are among the TOP 5 brands.

• Scientific Leadership: This role is the key internal and external scientific representative, responsible for interpreting clinical data, bridging gaps, and building scientific networks regionally and internationally.
• Pipeline Readiness for Oveporextone: The role is critical in ensuring organizational and market readiness for future pipeline launches like oveporextone, including scientific education, stakeholder engagement, and early access strategies.
• Addressing Unmet Clinical Needs: There are significant data gaps in therapeutic areas that require expert interpretation and dissemination.
• Healthcare Reform Engagement: Takeda is involved in Kazakhstan’s health reforms, particularly in orphan diseases, patient management, digital medical records, and diagnostics.
• Collaborative Partnerships: The role fosters collaboration with key partners (e.g., Orphan Center, Damumed) to improve disease awareness and digital patient navigation, especially under existing MoUs.
• Business Continuity Risk: Not filling this position may lead to declines in disease diagnosis and treatment rates, especially for Fabry and MPS

DIMENSIONS AND ASPECTS:

Technical/Functional (Line) Expertise

Possesses in-depth medical and scientific expertise in rare disease management, with solid grounding in biostatistics, clinical data interpretation, and the fundamentals of medical science. Demonstrates thorough understanding of healthcare systems and the patient journey in orphan diseases. Skilled in developing and executing medical strategies, producing high-quality medical content, and delivering impactful presentations and training. Proficient in leveraging MS Office and AI tools to enhance efficiency and communication.

Leadership

Shapes the vision and drives medical strategy for genetic diseases, ensuring strong alignment with Takeda’s business objectives. Leads and inspires cross-functional teams, manages complex changes in healthcare reform and product launches, and excels in scientific communication. Directly supports the development of 6 MSLs (dotted-line management), fostering their growth through clear strategic direction, goal setting, and KPI alignment, while equipping them with the necessary resources for success.

Decision-making and Autonomy

Exhibits high autonomy in mastering complex medical fields and developing annual plans aligned with company and department objectives. Demonstrates sound judgment in navigating multifaceted tasks, organizing work for self and others, and proactively seeking support when needed. Makes impactful decisions on scientific priorities and resource allocation that influence patient outcomes and business performance. Anticipates potential challenges, utilizes structured problem-solving, and adapts to evolving situations. Always acts with ownership and accountability while ensuring strict adherence to Takeda’s policies, procedures, and reporting structures.

Interaction

Serves as the primary scientific point of contact within the medical department, leading GD discussions for 1 MSL Lead, 6 MSLs, and the medical project manager to drive the success of medical omnichannel campaigns. Acts as a key scientific counterpart to the GD product manager, market access colleagues, and the Government Relations (GR) team. Contributes to the localization of labeling documents in close collaboration with the regulatory department and ensures the implementation of aRRMs by the local operating company (LOC). Represents Takeda’s scientific voice externally in meetings with academic KOLs, healthcare practitioners, health administration officials, digital health solutions representatives, and patients. Leads pipe-line discussions for oveporexton externally and internally, develops and implements pre-launch medical plans, and active memebre of EAMEA pipe-line team.

Innovation

Demonstrates continuous growth in medical science, looking for the forefront of R&D innovation. Proactively seeks out scientific discoveries related to Takeda’s therapeutic areas and products, applying them to local medical strategy where appropriate. Motivates subordinates and peers to advance their knowledge and supports their practical application. Fosters an open environment for the exchange of ideas and provides strong informational support. Shows curiosity about new ways of working and is an early adopter of AI and other technologies. Carefully weighs risks and makes decisions based on PTRB principles, taking responsibility for both successes and failures.

Complexity

Manages all medical activities for the GD portfolio (Replagal, Elaprase, and Vpriv) and develops the future medical strategy for the pipeline product Oveporextone. Partners with marketing and brand teams to facilitate scientific discussions and oversees the creation and implementation of medical plans that are balanced with commercial strategy. Promotes effective medico-commercial collaboration while maintaining clear boundaries between the roles of medical affairs and commercial objectives. Embodies Takeda’s values, PTRB, and DE&I principles. Demonstrates agility and the ability to adapt in a BANI (Brittle, Anxious, Nonlinear, Incomprehensible) environment. Experienced in managing top KOLs, with a science-based approach and a focus on mutual benefits rooted in PTRB.

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

• MD, Master’s, or scientific degree is considered an additional advantage.
• Experience in a medical role within the pharmaceutical industry.
• Knowledge of evidence-based medicine, including basic biostatistics and GCP.
• Proficient user of MS Office.
• Confidence in using AI for scientific education, clinical trial assessment, and the development of medical materials.
• Excellent communication and presentation skills.
• Demonstrates integrity and a growth mindset.
• Proficiency in English and Russian is required; medical proficiency in Kazakh is an advantage.

More about us: 

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work. 

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. 

Empowering our people to shine: 

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, or any other characteristic protected by law. 

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