2025 Summer Internship – Biotherapeutics Process Development – Downstream Early Stage – Highthroughput

The Biologics Process Development team's mission is to develop and implement manufacturing processes that ensure reliable supply of drug substance for clinical and commercial biotherapeutic products through the application of science and cross functional teamwork. The purification/downstream team, as a sub-function, supports the development of processing desired yield and purity of a target bioproduct as drug substance using separation techniques.

Job Description:

The downstream process development (DSP) internship project during summer of 2025 (June – August) focuses on high-throughput (HTP) workflow with enhanced automation for buffer preparation capability. A dedicated liquid handler (LH) and 4-probe micro pH meter has been acquired to accelerate a 96-well plate screening workflow. The goal of the project is to integrate the updated HTP buffer creation equipment and demonstrate timesaving realization (reduce 1-day requirement down to 1-2 hours).

How You Will Contribute:

Internship responsibilities include

• Assessing current DSP lab buffer preparation practice and capabilities
• Demonstrating accurate production of HTP buffer preparation by Lynx LH
• Performing a use-case study(s) /applicability of the HTP buffer on a 96-well plate format screening e.g., optimizing molarity/pH for chromatographic elution conditions
• Presenting economics/advantage (or other findings) of highthroughput buffer preparation
• Authoring user guidance documents including and not limited to principles on biological buffers, development workflow/playbook, and equipment operation. Work performed is expected to add value to strengthen the usability of HTP in DSP workflow, e.g. screening at early stages of process development.
  

Internship Development Opportunities:

• Intern will learn to use highthroughput liquid handlers such as Lynx, Dynamic Devices and Evo Freedom, Tecan
• Learn about antibody platform downstream purification scheme
• Broaden knowledge of biological buffers in antibody purification, as well as mechanism of action on bio-separation techniques such as chromatography.

Job Requirements:

• This position will be Fully Onsite and require 4+ days in the Lexington office per week.
• Must be pursuing a Bachelor's, Master's , or Doctoral degree in Chemical, Biochemical, Biotechnology, Biopharmaceutical Engineering, or related fields
• Basic understanding of computer skills including MS Office (PowerPoint, Words, Excel)
• Internet skills including use of e-mails, group messaging and information gathering
• Highly reliable and a strong team player
• Flexible with an attention to detail
• Strong verbal and written communication skills

Internship Eligibility

• Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship
• Must be currently enrolled in a degree program graduating December 2025 or later
• The internship program is 10-12 weeks depending on the two start dates(June 2nd- August 22nd)or(June 16th -August 29th)
  • The intern must be able to commit to one of these time frames
• Able to work full time 40 hours a week during internship dates
• Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program

 Program Highlights:

• Hands-on experience with real projects and responsibilities
• Dedicated mentorship program pairing interns with experienced professionals
• Networking opportunities with industry professionals and fellow interns
• Internship events focused on professional and skills development
• Exposure to multiple business areas or departments within a Pharmaceutical Organization

Applications will be accepted between December 18th and January 10th

Takeda Compensation and Benefits Summary

We understand compensation may bean important factor as you consider an internship opportunity. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.