2025 U.S Summer Internship Program: Lead Discovery In-Vitro Pharmacology Intern

Proximity-induced targeted protein degradation is a therapeutic modality that offers the potential to modulate previously undruggable targets, expanding therapeutic possibilities for a range of diseases. With this therapeutic approach, heterobifunctional molecules tag proteins for degradation by the cell’s degradation machinery, resulting in functional inhibition of the target protein or pathway. This work aims to utilize high-throughput screen (HTS) to assess diverse compound libraries and search for small molecules degraders that can serve as starting point for therapeutics.

How You Will Contribute:

• The intern will work closely with the IVP team to gain practical experience in cellular assays including viability and compound efficacy screens, compound management, and data analysis, contributing to high-throughput screening and selectivity profiling for molecular degraders.

Internship Development Opportunities:

• The internship provides insights into the inner workings of early stage drug discovery. The intern will employ automated HTS technologies including robotics and liquid handling platforms to screen chemical libraries against targets of interest, and gain deeper understanding about the role of HTS in small molecule discovery. The intern will also learn to utilize cloud-based systems approaches for analysis, reporting, and storage of data. Finally, this opportunity implores the ability to critically think through experimental questions, allowing growth in a collaborative environment while contributing to groundbreaking research.
  

Job Requirements:

• This is an in-person position (5 days per week) located in Cambridge, MA
• Candidates must be currently enrolled and pursuing a Bachelor's degree
• Experience in routine cell culture techniques, including passaging, freezing, and thawing cells. Good understanding of aseptic techniques and sterile handling of mammalian cell cultures
• Experience in using laboratory equipment, such as microscopes and cell counters
• Knowledge of cell-based assays, including viability and cytotoxicity screens
• Proficiency in Microsoft Excel and data analysis applications
• Excellent organizational skills and attention to detail
• Strong verbal and written communication skills

Internship Eligibility

• Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship
• Must be currently enrolled in a degree program graduating December 2025 or later
• The internship program is 10-12 weeks depending on the two start dates (June 2nd- August 22nd) or (June 16th - August 29th)
  • The intern must be able to commit to one of these time frames
• Able to work full time 40 hours a week during internship dates

• Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program
  

 Program Highlights:

• Hands-on experience with real projects and responsibilities
• Dedicated mentorship program pairing interns with experienced professionals
• Networking opportunities with industry professionals and fellow interns
• Internship events focused on professional and skills development
• Exposure to multiple business areas or departments within a Pharmaceutical Organization

Applications accepted between December 18th and January 12th

Takeda Compensation and Benefits Summary

We understand compensation may bean important factor as you consider an internship opportunity. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.