Scientist, Biologics Expression

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Job Description

Job Description [Research Scientist, Biologics Generation & Analytics]

We are seeking a highly skilled and motivated Research Scientist to join Biologics Generation & Analytics (BGA) group of Global Biologics. The ideal candidate will possess strong background in protein production and characterization using mammalian expression platforms and contribute to antigen and tool molecule production to advance Takeda’s therapeutic discovery programs.  A successful candidate will collaborate with matrixed project teams, internal protein production and analytical experts and execute protein production requirements. Effective communication skills and the ability to work within cross-functional teams are essential.

 The successful candidate will:

• Design and engineer constructs for protein expression, including reformatting antigens/antibodies and applying advanced protein engineering solutions (innovative non-antibody fusions and different modalities of therapeutics) to improve expression performance.
• Perform protein expression using mammalian expression system, including HEK293 and CHO cell lines at small- to large-scale. The scope of expression work includes the use of high-throughput automation system, shake flasks, to WAVE bioreactor with perfusion setup.
• Support downstream process, including purification and analytical characterization to ensure high-sample quality that fits project needs.
• Evaluate and implement new methods for transient and stable pools on protein expression when appropriate.
• Maintain responsibility for routine laboratory instrumentation and supplies.
• Document experiments thoroughly using LIMS systems and communicate results within the team and cross-functional groups.

Desired qualifications include:

• PhD degree in a scientific discipline (or equivalent), or MS with 6+ years relevant experience, or BS with 8+ years relevant experience. Strong preference for protein production experience in an industry setting.
• Track record of hands-on experience with high-quality protein production (construct design, expression, purification, optimization, characterization) of antigens, antibodies and/or other biologics therapeutics for drug discovery is required.
• Experience in HEK- and CHO-based protein expression (transient and stable) at a variety of scales, including plate-based formats and fermenters or wave bioreactor, is required.
• Experience with antibody purification approaches (including common chromatography), with a track record of being able to adapt these protocols or develop new ones for challenging antibodies and antigens, is highly desirable.
• Strategic experiment planning, data interpretation, summarization, and presentation with minimal supervision are required. Effective verbal and written communication as well as strong interpersonal skills are required.
• Experience managing Co-ops, Research Associates and training fellow scientists is a plus.
• Experience protein production utilizing contract research organizations is a plus.
• Excellent trouble-shooting and organizational skills and attention to details.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$111,800.00 - $175,670.00

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

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