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Digital Scientist, CMC

Boston, Massachusetts
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  • Job Level: Senior
  • Travel: 5-10%

The Pharmaceutical Sciences (Pharm Sci) organization is an integral part of global R&D at Takeda, translating science into therapeutic products for patients. When you join Pharm Sci, you become part of a team dedicated to bringing our products to life for our patients through innovation, dedication and talent while minimizing environmental impact.

We work as a member of Takeda’s Global Program Team (GPT) and take full ownership of Chemistry, Manufacturing & Control (CMC) activities — driving product development from bench to bedside.

The Pharm Sci team focuses on executing and enhancing business processes and partnering with key stakeholders and industry leaders to boldly deliver an increasingly complex portfolio. Always looking through a sustainability lens to protect our planet, we are embracing new ways of working, excelling in our data and digital transformation, building differentiated capabilities (CMC Acceleration), delivering innovative medical devices, and advancing an inclusive, innovative culture.

It is an exciting time to be in Pharm Sci. Join our journey and change the lives of patients!

Job ID R0148921 Date posted 04/03/2025 Location Boston, Massachusetts

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Join as a Digital CMC Scientist to support the planning, development and execution of the In Sillico First Initiative within Takeda’s Pharmaceutical Sciences organization. This exciting opportunity is perfect for experienced candidates who are curious, eager to learn, and open to working in a global setting on a variety of tasks related to data modeling, data fabric / architecture, and integrated process development workflows in the pharmaceutical R&D context.

In this role, you will work closely with the Sustainable CMC and Innovation team as well as capability leads from all development functional area to help establish process models, data structures, development workflows, and best practices in an environment where formalized regulatory guidance is still evolving. You will play a key role in supporting the implementation and operationalization of proof-of-concept development workflows, resulting in a paradigm shift that emphasizes In Silico methods as the basis of reducing overall development effort.

OBJECTIVE:

  • Support the build & deployment of industry-leading in silico predictive models (both statistical & first principle) to support full integration of platform performance workflows to advance pipeline programs which fulfill In-Silico initiative deliverables.

  • Support the collection & analysis of structured & unstructured product & process data and generate scientific reports including conclusions & recommendations. 

  • Undertake scientific research, complex troubleshooting & problem-solving activities applying Machine/Deep Learning.

  • Be recognized as a technical resource & expert in PSST for mathematical modeling, harnessing next generation capabilities in the field of Data Science and utilization of his/ her technical expertise to contribute across multiple projects and drive technical & scientific strategy.

  • Keep abreast of technological advances specific to Digital Acceleration, Data Science, Data Engineering, Computational Process Development, Systems Biology, and Advanced Process Control.

ACCOUNTABILITIES:

  • Support projects, primarily within a framework of the In-Sillico First initiative via the following: Review, interpret & communicate data cross-functionally across PharmSci and project teams. Perform Statistical/Machine/Deep Learning and other advanced data techniques for the purpose of deriving better insights from available datasets. Understand and use different Supervised and Unsupervised learning techniques, their biases, how and when to apply them and which methods are the best for a particular analysis. Be proficient at wrangle raw data sets into a format that can have advanced methods applied against the resulting data.

  • Responsible for collaborating with PharSci functions to encourage technical alignment & successful achievement of shared goals. Leverages technical skills as a resource/expert across PharmSci.

  • Contribute to project work which may include multiple projects within functional area.

  • Plan and implement resolutions to technical problems/issues, recommends and implements technologies and innovations.

  • Responsible for authoring relevant sections of regulatory documents, report and peer-reviewed manuscripts.

  • Collaborate with vendors and build relationships to gain access to technologies as needed to deliver on pipeline goals.

  • Act as a technical expert for emerging digital capabilities

EDUCATION, EXPERIENCE AND SKILLS:

Education and Experience:

  • Bachelors degree in Data Science, Statistics, Bio-Informatics, Mathematics, Chemometrics, Chemistry, Biology, Engineering or related pharmaceutical science and 8+ years relevant industry experience, or

  • Masters degree in Data Science, Statistics, Bio-Informatics, Mathematics, Chemometrics, Chemistry, Biology, Engineering or related pharmaceutical science 6+ years relevant industry experience, or

  • PhD in Data Science, Statistics, Bio-Informatics, Mathematics, Chemometrics, Chemistry, Biology, Engineering or related pharmaceutical science and 0+ years relevant industry experience

Technical Skills

  • Experience in the use of mathematical, both statistical and first principle, models as well as advanced process control systems

  • Solid knowledge of the pharmaceutical industry and its R&D

  • Comfortable working in the according Data Science environment: using frameworks (e.g. Python, MATLAB, R, JMP), considering industrial Data Engineering protocols (e.g. OPC, Modbus) and repositories (e.g. SQL, Oracle, AWS)

  • Ability to analyze a wide variety of information and data to make management decisions regarding potential risks associated with product quality and regulatory compliance.

  • Sound knowledge of current GxP

  • Proven scientific track record through presentations at scientific conferences and publication of peer-reviewed manuscripts

  • Some experience in Project Management

Communication & Leadership Skills:

  • Experience in working in a multi-disciplinary team environment

  • Demonstratable critical and out-of-the-box thinking ability

  • Understanding of the structure, functions, and methods of the global Takeda organization and overall Takeda R&D operations.

  • Excellent organizational and communication skills. Develops and maintains relationships with colleagues within manufacturing and research networks to identify & support potential value-creating opportunities. Demonstrates ability to negotiate difficult issues and arrive at mutually beneficial solutions

  • Robust communication skills are necessary for explaining complex concepts and policies across all organizational levels and to external stakeholders. This also includes the ability to mentor teams on knowledge and data governance standards and practices.

Regulatory Knowledge:

  • Understanding of cGMP requirements, and some experience with pharmaceutical regulatory documents

  • Familiarity with recent regulatory guidance on the use of models for new drug production applications

  • Knowledge of current and upcoming regulatory requirements around data modeling, data integrity, including comprehensive understanding of ALCOA++ principles

Leadership Behaviors:

  • Candidates must demonstrate Takeda's core leadership behaviors—integrity, accountability, collaboration, and innovation. This includes maintaining ethical standards, taking proactive responsibility for data outcomes, effectively collaborating across diverse teams, and continually seeking innovative approaches to enhance data governance.

Problem-Solving Skills:

  • Strong analytical and problem-solving skills are essential for identifying and addressing issues, developing effective solutions, and implementing changes that enhance data integrity and operational efficiency.

TRAVEL REQUIREMENTS:

May require approximately 5-10% travel

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$111,800.00 - $175,670.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
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Where you fit in

Our teams are experienced in medicinal chemistry, multi-step synthesis, multimodal genetics, genomics datasets, pharmacokinetics and more. So wherever your expertise and passion lie, your work will have tangible outcomes, advancing an innovative pipeline that serves unmet needs.

We're delving deeper than ever inside the human body and its microbiome, implementing innovative approaches to deliver high-quality products that treat a range of illnesses, including IBD and cancer.

In our diverse, forward-thinking culture, we're constantly embracing new ways of working:

  • Partnering with research teams, GPTs, business development and our commercial partners in GMS/GQ
  • Supporting all stages of pre-clinical and clinical development
  • Providing enabling technologies, including formulation and delivery strategies, analytical expertise and IP
  • Developing processes to manufacture high-quality Clinical Trial Material and other
  • Focusing on broad therapeutic areas on multiple device platforms: Advanced Delivery Devices, Home & Point-Of-Care Diagnostics, Software & Connectivity for eHealth devices and state-of-the-art Medical Devices & Combination Products

On our team in Pharmaceutical Sciences, you’ll notice a big difference in your own life, too. You’ll be supported to develop your career. You'll connect with brilliant minds and be recognized for your accomplishments. Your curiosity, skills and dedication will have a place and a purpose. So even when you’re exploring the smallest of details, your world will be bigger than ever.

  • Perform cell processing operations

  • Support clean room activities

  • Ensure equipment maintenance

  • Support investigations in deviations

Along with incredibly passionate colleagues, there’s a clear commitment to invest in the best facilities and the right equipment needed to successfully perform world-class science.
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Christina Alves - Head of Biotherapeutics Process Development

Within Takeda, there’s a lot of room for disruption and challenging how things have been done before.
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Briana Rawson - Lead, Human Factors Engineer

I love that I get to connect smaller, newer ventures with Takeda’s reputation and resources so that we can develop innovative ways of diagnosing and managing the conditions of patients with unmet needs.
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Rachel Whitaker - Principal Engineer, Diagnostic Devices

The heart of our work

Leading with innovation

Our pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

Learn more

What we believe in

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

  • Integrity

  • Fairness

  • Honesty

  • Perseverance

Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.
  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.
  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 17 companies to receive Top Global Employer® status for 2024.
  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.
  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

We're Steadfast In Our Commitment to Four Key Imperatives

Patient


Responsibly translate science into highly innovative medicines and accelerate access to improve lives worldwide.

People


Create an exceptional people experience.

Planet


Protect our planet.

Data & Digital


Transform Takeda into the most trusted, data-driven, outcomes-based biopharmaceutical company.

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About our location

Boston, Massachusetts


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