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Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as a Biomarker Senior Scientist where you will work in the Gastroenterology Drug Discovery Unit (GI DDU) and lead efforts focused on the discovery and validation of novel biomarkers for certain drug targets in liver fibrosis and other chronic liver diseases. You will have a strong scientific background in liver fibrosis and/or metabolic diseases with experience in biomarker identification and development. You will also be responsible for biomarker discovery and validation efforts for novel targets and drug candidates and independently design and implement extensive biomarker research strategies to support multiple projects in collaboration with internal research teams, external partners and/or CROs. As part of the Liver Disease Research team, you will report to the Associate Scientific Director and work with the GI DDU.

How you will contribute:

• Develop and implement new biomarker concepts for the treatment of liver fibrosis and other chronic liver diseases. This includes biomarker identification, development and validation etc.

• Develop and oversee novel scientific biomarker projects in collaboration with internal and external partners.

• Establishes project direction integrating science, key technical knowledge, and program objectives.

• Manages relevant biomarker strategy for target and drug candidate discovery, validation and mechanism of action studies using contemporary in vitro/ in vivo methods and tools.

• Participate on cross-functional teams and provide technical leadership in area of expertise.

• Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas.

• Prepare technical reports, summaries and quantitative analyses in written and/or oral form.

• Communicate with colleagues effectively.

• Present data to other scientific staff or cross-functional project team; may present data/posters to external research or scientific community and publish research results as appropriate.

• Act as a biomarker lead to be involved in different stages of portfolio projects to provide input and contribute to Go or NoGo decisions for various milestones.

• Performs as a role model supporting Takeda culture and follow policies.

Minimum Requirements/Qualifications:

• Ph.D. degree in biology, cardio/metabolic diseases, or immunology or molecular pharmacology with 3+ years relevant post-doc experience or equivalent drug discovery experience in a biotech or pharmaceutical industry research setting with an additional 2+ years of experience, or

• MS with 9+ years of experience, or

• BS with 11+ years’ experience.

• Previous experience in relevant protein and RNA-based assays as well as use of multiomic approaches for biomarker discovery, validation or development is required.

• Previous experience in NASH/chronic liver disease or fibrotic diseases or understanding of liver disease pathogenesis and pre-clinical therapeutic mechanisms of action research.

• Demonstrated ability to independently design and solve scientific problems using multiple, state-of-the-art technologies, experimental methods, and approaches is required.

• Demonstrated ability to generate and implement a biomarker discovery strategy for a program in an industry setting is required.

• Previous experience and lab skills to address various types of biomarkers, modalities, and matrices, across animal models and human samples is preferred.

• Previous experience with translational biomarker research and working experience with clinical samples is preferred.

• Previous experience of using Omics platforms and collaboration with computational biologists.

• Good understanding of current liver fibrosis biomarkers is a plus.

• Good project management skills with a good understanding in various scientific disciplines in drug discovery (Pharmacology, Toxicology, DMPK, etc.) is a plus.

• Demonstrated track record by publications in scientific journals.

• Good communication skills (oral, written, and presentation) and a good team player.

What Takeda can offer you:

• Comprehensive Healthcare: Medical, Dental, and Vision

• Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan

• Health & Wellness programs including onsite flu shots and health screenings

• Generous time off for vacation and the option to purchase additional vacation days

• Community Outreach Programs and company match of charitable contributions

• Family Planning Support

• Flexible Ways of Working

• Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Base Salary Range: $130,200.00 to $186,000.00, based on candidate professional experience level. Employees may also be eligible for Short-term and Long-Term Incentive benefits as well. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off. The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

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