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Senior Scientist/Associate Scientific Fellow – Process Research

Boston, Massachusetts
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  • Job Type: Full Time
  • Job Level: Senior
  • Travel: 5-10%

The Pharmaceutical Sciences (Pharm Sci) organization is an integral part of global R&D at Takeda, translating science into therapeutic products for patients. When you join Pharm Sci, you become part of a team dedicated to bringing our products to life for our patients through innovation, dedication and talent while minimizing environmental impact.

We work as a member of Takeda’s Global Program Team (GPT) and take full ownership of Chemistry, Manufacturing & Control (CMC) activities — driving product development from bench to bedside.

The Pharm Sci team focuses on executing and enhancing business processes and partnering with key stakeholders and industry leaders to boldly deliver an increasingly complex portfolio. Always looking through a sustainability lens to protect our planet, we are embracing new ways of working, excelling in our data and digital transformation, building differentiated capabilities (CMC Acceleration), delivering innovative medical devices, and advancing an inclusive, innovative culture.

It is an exciting time to be in Pharm Sci. Join our journey and change the lives of patients!

Job ID R0105628 Date posted 09/05/2023 Location Boston, Massachusetts

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?  Join us as a Senior Scientist/Associate Scientific Fellow in our Process Research group as part of the Synthetic Molecule Process Development (SMPD) department, located at our Cambridge, MA, office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and by being a values-led company.  To do this, we empower our people to realize their potential through life-changing work.  Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do.  We foster a diverse, equitable, inclusive, and collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.  Here, you will be a vital contributor to our inspiring, bold mission.

Pharmaceutical Sciences empowers innovative and flexible teams to enable fast global patient access to high-quality products through a collaborative, data-driven culture that develops and applies adaptive, forward-thinking technologies into predictive and sustainable solutions across a diverse pipeline. As part of Pharmaceutical Sciences, SMPD Process Research is responsible for advancing novel synthetic molecule pharmaceuticals through the pre-clinical stage into early clinical development while operating in a highly dynamic environment with rapidly changing priorities. Key objectives will be the development of robust, safe, and scalable processes for the manufacture of such pharmaceuticals in a fit-for-purpose manner, along with methods for achieving and controlling high standards of purity and quality.


As a subject matter expert in synthetic organic chemistry, the successful candidate combines their expertise in synthetic organic chemistry, reaction mechanisms, and retro-synthetic analysis skills with their demonstrated, deep understanding of the development of phase-appropriate manufacturing processes that are amenable to safe scale-up and efficient enough to rapidly supply program-enabling drug substance in sufficient quantities and quality in a timely manner.

As part of this role, the successful candidate is expected to operate with a high degree of independence and possesses the skills and experience necessary to lead the overall drug substance (API) development efforts toward a successful GMP manufacturing campaign in support of Phase 1 clinical trials. It will be their responsibility to lead and drive the technical advancement of a given program by conducting personal in-house laboratory research efforts toward innovative, value-creating solutions, which guide and augment process development efforts at our external CDMO partners.

The successful candidate will be accountable for developing, leading, and executing complex scientific strategies for one or more pipeline projects. Within their field of expertise as a Senior Scientist/Associate Scientific Fellow, the successful candidate will actively contribute to decision making on multidisciplinary technical teams. This includes close interaction with Takeda’s discovery functional lines such as Medicinal Chemistry, DMPK, Drug Safety, and Pharmaceutical Sciences cross-functional and cross-site teams as well as with our external partners (CDMOs).

The successful candidate will be open to embracing the implementation of technologies (e.g. flow chemistry, Process Analytical Technologies (PAT), automation, artificial intelligence, kinetic modeling, etc.) and emerging innovation in organic chemistry (such as photo redox, electrochemistry, etc.) early in the development lifecycle to enhance development capabilities.


  • Designs scalable synthetic routes, and solves synthetic chemistry problems.

  • Analyzes and interprets scientific data independently.

  • Designs phase-appropriate strategies for reaction optimization, and scale-up demonstration, and conducts troubleshooting experiments to achieve project goals.

  • Develops strategies and independently executes the plan for the preparation of gram-to-kilogram quantities of APIs, intermediates, impurities, and reference standards, and/or assists in the management of such activities at our external CDMOs.

  • Maintains a current understanding of synthetic organic chemistry literature and technology trends/advancements.

  • As necessary, prepares experimental procedures for patent applications and scientific reports as well as tech transfer documents in support of collaborations with Takeda’s external partners (CDMOs).

  • Actively builds the necessary cross-functional and cross-site relationships in support of early-stage Pharmaceutical Sciences development.

  • Serves as a subject matter expert and collaborates with other Pharmaceutical Sciences functions (Analytical Development, Drug Product Development, etc.) in support of the development and implementation of an overall CMC strategy.

  • Ability to lead all or part of the SMPD efforts on a program, represent SMPD in cross-functional meetings and lead technical efforts at multiple CDMOs.

  • Plays an important/key role in actively contributing to the development of a CMC strategy and related timelines (including Gantt charts) as a Drug Substance Lead, proactively balances risks against project needs, and communicates progress and related plans in a timely and transparent manner.
  • Depending on the level of experience and expertise, this role includes the opportunity to lead a cross-functional CMC team consisting of Drug Substance Development (SMPD), Analytical Development, Drug Product Development, and adjacent functions (such as QC, QA, CMC regulatory affairs, clinical supply chain) with full accountability for the CMC strategy and its successful execution.
  • Presents results and process chemistry related matters; manages process chemistry related activities.
  • Establishes metrics and has accountability for progress against project goals; regularly determines research project deadlines and objectives.

Education and Experience:

  • A Ph.D. degree (strongly preferred) in organic chemistry with a focus on total synthesis or methodology development and 3+ years (7+ years for ASF) of relevant pharmaceutical industry experience; an MS degree with 9+ years (13+ years for ASF) of relevant pharmaceutical industry experience; or a BS degree with 11+ years (15+ for ASF) of relevant pharmaceutical industry experience.
  • Expert understanding of a wide range of synthetic organic chemistry, including reaction mechanistic aspects and synthetic route design (retrosynthetic analysis), paired with excellent laboratory and productivity skills.

  • A high level of proficiency in multi-step synthesis, purification, and characterization of complex organic molecules using the latest techniques.

  • Experience with process research/synthetic route scouting and a demonstrated, deep understanding of the principles of process development is mandatory.
  • Experience in the use of technologies (e.g. flow chemistry, photo redox chemistry, Process Analytical Technologies (PAT) such as FT-IR, NIR, FBRM, UV-vis, etc., automation, artificial intelligence, kinetic modeling, etc.) and an interest in application to early-stage development programs is considered a plus.

  • Experience with cGMP production, sound knowledge of regulatory requirements as well as composing of CMC sections of regulatory documents for Phase 1 IND filings is required.
  • Experience in introducing synthetic/manufacturing technologies into a GMP setting and working in a multi-disciplinary team is required.

Competencies and Skills

  • Analytical and Problem-Solving Skills – Ability to troubleshoot critical issues or problems using appropriate information and determine causes and possible solutions.

  • Teamwork – Builds a collaborative network of relationships with people in a variety of functions and roles; and leverages formal and informal networks to accomplish goals. Promotes shared responsibility for getting things accomplished across our organization.

  • Communication Skills – Communicates complex information clearly and engagingly; documents issues and/or concerns concisely with colleagues; asks for and provides the right amount of information to meet the needs of management, direct reports, and project teams; adjusts communication style as appropriate for the audience; proactively and effectively communicates with stakeholders and management; technical writing skills to support authorship and approval of internal technical documents.

  • Technical – Subject matter expertise in one or more specific scientific area(s) of organic chemistry as well as multi-step synthesis of pharmaceutically active ingredients.

  • Resource Management – Ability to manage timelines as well as individual, departmental, and project goals; effective management of internal and external resources (CDMOs)

  • Leadership Skills – Identifies opportunities and demonstrates initiative towards the accomplishment of department/function goals and objectives.

  • Development/Growth – Possesses self-awareness and a learning-oriented mindset with a desire to continually build and grow leadership, management, and technical skills to elevate personal, team, and organizational performance and capabilities.


  • On-site role in Cambridge, MA

  • Some domestic and international travel may be necessary.

  • Ability to travel to meetings or external vendor/CDMO sites, including overnight trips.

  • Requires less than 10% travel.


  • Comprehensive Healthcare: Medical, Dental, and Vision

  • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan

  • Health and wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs and company match of charitable contributions

  • Family Planning Support

  • Flexible Work Paths

  • Tuition reimbursement

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Boston, MA

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Where you fit in

Our teams are experienced in medicinal chemistry, multi-step synthesis, multimodal genetics, genomics datasets, pharmacokinetics and more. So wherever your expertise and passion lie, your work will have tangible outcomes, advancing an innovative pipeline that serves unmet needs.

We're delving deeper than ever inside the human body and its microbiome, implementing innovative approaches to deliver high-quality products that treat a range of illnesses, including IBD and cancer.

In our diverse, forward-thinking culture, we're constantly embracing new ways of working:

  • Partnering with research teams, GPTs, business development and our commercial partners in GMS/GQ
  • Supporting all stages of pre-clinical and clinical development
  • Providing enabling technologies, including formulation and delivery strategies, analytical expertise and IP
  • Developing processes to manufacture high-quality Clinical Trial Material and other
  • Focusing on broad therapeutic areas on multiple device platforms: Advanced Delivery Devices, Home & Point-Of-Care Diagnostics, Software & Connectivity for eHealth devices and state-of-the-art Medical Devices & Combination Products

On our team in Pharmaceutical Sciences, you’ll notice a big difference in your own life, too. You’ll be supported to develop your career. You'll connect with brilliant minds and be recognized for your accomplishments. Your curiosity, skills and dedication will have a place and a purpose. So even when you’re exploring the smallest of details, your world will be bigger than ever.

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The heart of our work

Leading with innovation

Our pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

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What we believe in

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

  • Integrity

  • Fairness

  • Honesty

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Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.
  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.
  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 15 companies to receive Top Global Employer® status for 2023.
  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.
  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

We're Steadfast In Our Commitment to Four Key Imperatives


Responsibly translate science into highly innovative medicines and accelerate access to improve lives worldwide.


Create an exceptional people experience.


Protect our planet.

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Transform Takeda into the most trusted, data-driven, outcomes-based biopharmaceutical company.

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About our location

Boston, Massachusetts

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