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Research Senior Scientist / Principal Scientist, Immunology, Oncology Cell Therapy Innovation

Boston, Massachusetts
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  • Job Type: Full Time
  • Job Level: Senior
  • Travel: Minimal (if any)

At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.

Job ID R0102974 Date posted 08/02/2023 Location Boston, Massachusetts

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Senior Scientist / Principal Scientist, Oncology Cell Therapy Innovation in our Cambridge, MA office. At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission.

The vision of Takeda is to build a world-class Cell Therapy team and deliver allogeneic innate cell therapy products to bring hope to both hematological and solid tumor patients. Oncology Cell Therapy Innovation is missioned to develop innovate innate cell platforms and novel engineering approaches to drive the discovery pipeline for Takeda Cell Therapy.


This position is seeking an experienced and highly motivated immunologist, who has a solid background in immunology, especially immuno-oncology and innate cell biology, to join the Cell Therapy Experimental Immunology team. We are looking for someone who is highly dedicated and driven to advance new therapies to patients and who has a strong work ethic, drive and collaborative mindset. The candidate will lead efforts in identifying new ways to optimize CAR-NK and CAR-γδT cell platforms byimproving our understanding of the basic biology of NK and γδT cells. The focus will be in discovering new ways to improve potency, persistence and immune modulation through developing a solid understanding of activation, survival, costimulation, differentiation, and suppressive mechanisms affecting these cells. The principal scientist will lead discovery projects and collaborate with colleagues within and across departments.

How you will contribute:

  • Contribute to pre-clinical/discovery work by designing, executing and leading experiments to further understand key pathways and mechanisms driving NK and γδ T cells biology

  • Lead from the lab to advance novel and differentiated cell therapy products toward clinical milestones, by working collaboratively with internal cross-functional teams and external partners.

  • Design, execute, and interpret functional in vivo, in vitro, and ex vivo assays to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions.

  • Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans/value, and research results.

  • Prepare and present comprehensive technical or project reports and formal presentations/posters to full range of internal/external audiences.

  • Ability to work independently and prioritize work in a fast-paced environment.

  • Maintain laboratory notebooks and follow laboratory practices in compliance.

  • Contribute to IND report and documentation.

  • Collaborate with cross-function teams and contribute in matrix-based project groups

  • Other job duties as assigned.

Minimum Requirements/Qualifications:

  • PhD degree in a scientific discipline with 6+ years experience, or MS with 12+ years experience, or BS with 14+ years experience

  • Minimum of 8+ years relevant pharmaceutical industry/academic experience post-graduation

  • Hands-on experience with CAR-T, CAR-NK, CAR-γδT, or TCR-T cell therapies/immunotherapies is required, including cell culture, immune cell activation/expansion, cytotoxicity assays, scRNAseq and high-throughput screening.

  • Profound skills in in vitro and in vivo immune cell characterization and functional assessment, such as, multi-color flow immunophenotyping, multiplex cytokine measurements, cytotoxicity assays, and other molecular based assays.

  • Experience with lentiviral transduction/CRISPR mediated KO/KI.

  • Excellent written and verbal communication skills, detail-oriented organization skills, and team collaboration skills.

  • Track record of publications to demonstrate scientific establishment.

What Takeda can offer you:

  • Comprehensive Healthcare: Medical, Dental, and Vision

  • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs and company match of charitable contributions

  • Family Planning Support

  • Flexible Ways of Working

  • Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.


EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Boston, MA

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Where you fit in

Our team at Takeda is tackling some of the most challenging problems in drug discovery and development. As the newest member of our Research team, you’ll conduct purposeful, meaningful work on groundbreaking modalities that may lead to breakthrough drugs.

With our deep investment in next-generation technologies, you’ll have the resources and support to do your best work. As a part of our team, you’ll connect with brilliant minds inside and outside of Takeda. We are committed to collaborating with academia and emerging biotech companies to expand our reach and impact in cell therapy, gene therapy and data sciences.

Our team’s wide-ranging expertise includes medicinal chemistry, genomics datasets, immunofluorescence, high content imaging, flow cytometry, transcriptional profiling, multi-step synthesis, multimodal genetics, pharmacokinetics and much more. Whatever area inspires you, your work will support the progression of an innovative, industry-leading discovery pipeline and make an impact that matters to patients and society.

A career in Research at Takeda will give you everything you need to succeed professionally — and make a difference to patients, people and the planet.

  • Design and carry out experiments

  • Manage multiple projects

  • Document data

  • Mentor other scientists

I feel especially lucky to be able to work with colleagues across the industry to meet a unified goal.Takeda is paving the way for how research will be conducted in the future.

Daniel Scheibe - Senior Manager Operations, Systems Engineering, Drug Discovery Sciences

Along with incredibly passionate colleagues, there’s a clear commitment to invest in the best facilities and the right equipment needed to successfully perform world-class science.

Christina Alves - Head of Biotherapeutics Process Development

Our pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

Learn more

What we believe in

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

  • Integrity

  • Fairness

  • Honesty

  • Perseverance

Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.
  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.
  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 15 companies to receive Top Global Employer® status for 2023.
  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.
  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

We're Steadfast In Our Commitment to Four Key Imperatives


Responsibly translate science into highly innovative medicines and accelerate access to improve lives worldwide.


Create an exceptional people experience.


Protect our planet.

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Transform Takeda into the most trusted, data-driven, outcomes-based biopharmaceutical company.

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About our location

Boston, Massachusetts

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