Research Scientist II, High-Throughput, Global Biologics
Research Scientist II, High-Throughput, Global BiologicsJob ID R0092364 Date posted Mar. 24, 2023 Location Boston, Massachusetts
About the role:
At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Join Takeda as a Scientist II where you will independently perform high-throughput cloning, mammalian transfection, purification and optimization work in efforts to advancing early therapeutic discovery using the latest automation technologies. You will also contribute to the design of new vector formats for increased expression of antibodies, bispecifics, and other biologic modalities and optimize expression conditions in plate format to increase protein production. As part of the, Therapeutic Generation and Screening team you will report to the Senior Scientist and participate on matrix project teams and interface with members of Biologics Engineering and other therapeutic groups.
How you will contribute:
Under minimal supervision, perform high-throughput (HTP) production of antibodies, bispecifics and protein antigens used to discover and advance novel therapeutics.
Help with the design of new vector formats that will be used for HTP protein production of bispecifics and multi-format biologics.
Have experience with transient expression and purification of protein constructs from a variety of mammalian host-cell systems using automated liquid handlers (Tecan, Hamilton, Dynamic Devices).
Produce plasmid DNA using high throughput cloning techniques.
Collaborate with automation engineers and independently implement solutions for protein production using a variety of automation equipment.
Perform cell culture work including the maintenance of cell lines.
Evaluate and implement new methods for high throughput protein expression and purification.
Perform data analysis and troubleshooting.
Summarize and communicate results at team meetings and contribute to scientific discussions.
Proficient at tracking data using LIMS systems and maintaining a detailed electronic notebook.
Initiate investigation of new experimental approaches to a wide range of problems using scientific theory and technical literature.
PhD degree in a Biology, Biochemistry, Molecular Biology, or related discipline with 2+ years experience, or
MS with 8+ years experience, or
BS with 10+ years experience
Strong background and experience in molecular biology, cloning, vector design, and mammalian cell culture. Also has experience with protein purification and LIMS, preferably GeneData Biologics.
Experience with molecular biology techniques and software such as SnapGene and Geneious Prime.
Previous experience in HTP platforms for biologics discovery required.
Experience in protein purification principles and methods.
Previous hands-on experience with laboratory automation and programming. Preferably with Dynamic Devices Lynx Instruments.
Track record demonstrating analytical and bench skills.
What Takeda can offer you:
Comprehensive Healthcare: Medical, Dental, and Vision
Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs and company match of charitable contributions
Family Planning Support
Flexible Work Paths
More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Time TypeFull time
- Job Type: Full time
- Job Level: Senior
- Travel: Minimal (if any)
At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.
- Design and carry out experiments
- Manage multiple projects
- Document data
- Mentor other scientists
Where You Fit In
Our team at Takeda is tackling some of the most challenging problems in drug discovery and development. As the newest member of our Research team, you’ll conduct purposeful, meaningful work on groundbreaking modalities that may lead to breakthrough drugs.
With our deep investment in next-generation technologies, you’ll have the resources and support to do your best work. As a part of our team, you’ll connect with brilliant minds inside and outside of Takeda. We are committed to collaborating with academia and emerging biotech companies to expand our reach and impact in cell therapy, gene therapy and data sciences.
Our team’s wide-ranging expertise includes medicinal chemistry, genomics datasets, immunofluorescence, high content imaging, flow cytometry, transcriptional profiling, multi-step synthesis, multimodal genetics, pharmacokinetics and much more. Whatever area inspires you, your work will support the progression of an innovative, industry-leading discovery pipeline and make an impact that matters to patients and society.
A career in Research at Takeda will give you everything you need to succeed professionally – and make a difference to patients, people and the planet.
I feel especially lucky to be able to work with colleagues across the industry to meet a unified goal. Takeda is paving the way for how research will be conducted in the future.Daniel Scheibe Senior Manager Operations, Systems Engineering, Drug Discovery Sciences
Along with incredibly passionate colleagues, there’s a clear commitment to invest in the best facilities and the right equipment needed to successfully perform world-class science.Christina Alves Head of Biotherapeutic Process Development
Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.Learn More
What We Believe In
Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.
Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.
We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.
Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.
Working at Takeda
Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.
A strong, borderless team, we strive together towards our priorities and inspiring mission.
Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
Recognized for our culture and way of working, we’re one of only 15 companies to receive Top Global Employer® status for 2023.
Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.
Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.
View All Research JobsSearch
Research Scientist I, GI DDU
San Diego, California Research & Development Apply for Research Scientist I, GI DDU
Research Scientist II: In vivo
Boston, Massachusetts Pharmaceutical Sciences Apply for Research Scientist II: In vivo
Senior Scientist, Biomarker Science and Technologies
Boston, Massachusetts Research & Development Apply for Senior Scientist, Biomarker Science and Technologies
We Take Action by Focusing on Our Four Priorities
- Create an exceptional people experience
- Responsibly translate science into highly innovative, life-changing medicines and vaccines
- Protect our planet
- Unleash the power of data and digital
Would you like to receive relevant opportunities in your inbox as soon as they’re posted?SIGN UP
Are you interested in company news, attending career events, and hearing more from Takeda?Join