Associate Scientist Pharmaceutics Research-Analytical DevelopmentBoston, Massachusetts
- Job Type: Full Time
- Job Level: Senior
- Travel: 5-10%
The Pharmaceutical Sciences (Pharm Sci) organization is an integral part of global R&D at Takeda, translating science into therapeutic products for patients. When you join Pharm Sci, you become part of a team dedicated to bringing our products to life for our patients through innovation, dedication and talent while minimizing environmental impact.
We work as a member of Takeda’s Global Program Team (GPT) and take full ownership of Chemistry, Manufacturing & Control (CMC) activities — driving product development from bench to bedside.
The Pharm Sci team focuses on executing and enhancing business processes and partnering with key stakeholders and industry leaders to boldly deliver an increasingly complex portfolio. Always looking through a sustainability lens to protect our planet, we are embracing new ways of working, excelling in our data and digital transformation, building differentiated capabilities (CMC Acceleration), delivering innovative medical devices, and advancing an inclusive, innovative culture.
It is an exciting time to be in Pharm Sci. Join our journey and change the lives of patients!
About the role:
At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Join Takeda as an Associate Scientist Pharmaceutics Research-Analytical Development where you will support the transition of novel compounds (synthetic molecules, Oligonucleotide, Protacs) from Discovery into Development, primarily physicochemical profiling, pre-clinical formulation research and biopharmaceutics. You will also be involved in continued research efforts throughout the developmental lifecycle of compounds across many activities. As part of the AD Pharmaceutics Research team, you will report to Senior Scientist and work with Discovery Teams, Drug Safety, DMPK and close collaboration with Process Chemistry, Formulation development and Analytical Development to achieve project goals.
How you will contribute:
Independently design, plan and execute studies on new development candidates to elucidate fundamental physicochemical properties and behaviors that enable lead candidate selection and downstream CMC development.
Contribute to a cross-functional Pharmaceutical Sciences team responsible for overseeing API salt and polymorph selection and subsequent development activities.
Use analytical techniques off line and potentially in line to characterize API form and morphology development.
Develop non-GLP and GLP formulations based on the physical chemical properties of molecules and their route of delivery to support pre-clinical studies.
Conduct biorelevant in vitro studies to assess potential in-vivo performance/impact of API and drug product changes during development lifecycle.
Responsible for significant or sole technical leadership within a project and support project strategy development across projects within the department or cross functionally.
Interface with individual Pharmaceutical Science colleagues and cross functional project teams to ensure that development activities are consistent with physicochemical properties of API.
Represent functional area on departmental or cross functional teams communicating and aligning Pharmaceutics Research activities and milestones.
Collaborate with Drug Safety to transfer formulations to CRO’s for non-GLP and GLP toxicology studies.
May serve as a technical expert/SME for mentoring of junior team members.
Integrate scientific/technical efforts around cross functional issues.
Plan and implement resolutions to technical problems/issues.
Support local initiatives which may include technical or process related work streams.
Author technical reports and contributes to regulatory filings.
Bachelors degree in Pharmaceutics, physical organic chemistry, pharmacy, or related pharmaceutical science with 5+ years of relevant industry experience.
Masters degree in Pharmaceutics, physical organic chemistry, pharmacy, or related pharmaceutical science with 3+ years of relevant industry experience.
Analytical and Problem Solving Skills - Able to troubleshoot critical issues or problems, and determine causes and identify/implement possible solutions.
Teamwork -- Ability to work well in highly cross functional team environment.
Communication Skills -Able to expresses one’s self clearly and concisely within teams; documents issues and/or concerns concisely with colleagues; timely and effective communication of issues to supervisor; technical writing skills to support authorship of internal technical documents.
Organization – Exercises good time management and prioritization skills and is able to successfully manage multiple tasks simultaneously.
Knowledge Sharing - Ability to capture organizational knowledge; improve solutions, processes, and deliverables through use of information.
Resource Management -Ability to manage one’s time within individual, departmental, and corporate goals and timelines; management of internal and external resources (vendors).
Technical - strong knowledge of physicochemical and preclinical formulation theory along with hands-on experience in multiple analytical techniques (DSC, TGA, HPLC, XRPD, Raman, PAT tools etc) and ability to work in a lab setting.
Working knowledge of modalities outside of traditional small molecule (Oligonucleotides, Protacs) and in silico predictive tools/modeling highly valued.
May require approximately 5-10% travel.
What Takeda can offer you:
Comprehensive Healthcare: Medical, Dental, and Vision
Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs and company match of charitable contributions
Family Planning Support
Flexible Ways of Working
More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Base Salary Range: $91,700 to $131,000, based on candidate professional experience level. Employees may also be eligible for Short-term and Long-Term Incentive benefits as well. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off. The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.
In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Time TypeFull time
The heart of our work
Leading with innovation
Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.
Working at Takeda
InclusionHere, you will feel welcomed, respected, and valued as a vital contributor to our global team.
CollaborationA strong, borderless team, we strive together towards our priorities and inspiring mission.
InnovationBold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
Top WorkplaceRecognized for our culture and way of working, we’re one of only 15 companies to receive Top Global Employer® status for 2023.
Work-LifeOur people-first mission extends beyond patients to include their families, communities, and our own Takeda family.
EmpowermentThrough trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.
We're Steadfast In Our Commitment to Four Key Imperatives
Responsibly translate science into highly innovative medicines and accelerate access to improve lives worldwide.
Create an exceptional people experience.
Protect our planet.
Data & Digital
Transform Takeda into the most trusted, data-driven, outcomes-based biopharmaceutical company.
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