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Process Engineer II (Downstream)

Singapore, Singapore
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On the Global Manufacturing and Supply (GMS) team at Takeda, you’ll be part of a rapidly transforming industry that’s applying technology and data in new ways. Within our agile, innovative, people-centric organization, your work will matter every day as you use your skills to help us manufacture therapies for patients on our four platforms:

  • Small Molecules
  • Biologics
  • Plasma
  • Cell and Gene

As part of the GMS team, you'll have the opportunity to pursue unique experiences and build new skills, and you'll know that the work you do every day makes an impact — on our patients, our people, our planet, and on yourself.

Job ID R0118352 Date posted 02/28/2024 Location Singapore, Singapore

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Job Title: Process Engineer II (Downstrea)
Location: Woodlands, Singapore

About the role:

  • Support/lead troubleshooting of manufacturing operations (Upstream/ Downstream) process/product issues

  • Technical subject matter expert (SME) for manufacturing operations to resolve process issues, perform root cause analysis and impact assessment for process investigations

  • Support evaluation of technologies, plan and execute process improvements

  • Support and execute global manufacturing science initiatives

  • Plan, support and execute site manufacturing science activities such as continuous process verification (CPV) program, technology transfer of new products and process monitoring and trending

How you will contribute:

Support site manufacturing (upstream) activities through

  • Planning and executing activities required for process investigation such as performing process impact assessment, participating and performing root cause analysis. Work with cross functional teams for process issues investigation
  • Analyzing process trends, monitoring process performance as part of the CPV program. Escalate and perform investigation in event of any out of trend or process issues
  • Leading process investigations to identify root cause and implement action plans to correct or prevent re-occurrence
  • Planning and executing process improvements and robustness projects
  • Leading/supporting cycle development for process parameters where applicable
  • Drafting process training slides and providing process training to cross functional teams
  • Raising change controls as change owners for process changes
  • Performing impact assessments for relevant change controls
  • Providing technical /process parameters for creation and revision of master batch records. Review master batch records.

Lead/Support technology transfer for new technologies/product introduction through

  • Leading/Supporting the evaluation of new manufacturing technologies and/or equipment for process improvement or process capabilities build
  • Planning and executing technical transfer activities according to project timelines. Raise change controls where applicable to support the technical transfer
  • Monitoring process performance and trending through the site CPV program. Proactively investigate where required to ensure process robustness.
  • Performing risk assessment, drafting required technical transfer and process control strategy documents and updating lifecycle documents
  • Authoring study and process validation protocols and reports where needed

Support audits, author regulatory submissions and responses

  • Support and execute global manufacturing sciences initiatives according to project timelines
  • Responsibility to adhere to any applicable EHS requirements.
  • Commitment to a fair and respectful relationship to others and behavior in accordance with Takeda’s Code of Conduct.
  • Any other duties as assigned by supervisor.

What you bring to Takeda:

 Education and Experience Requirements

  • Bachelor’s Degree in Biochemistry, Chemistry, Chemical Engineering, Biotechnology, Biochemical Engineering with minimum 3 - 4 years of relevant experience or Master’s Degree with 2 years of relevant work experience or a fresh PhD in the relevant technical area.
  • Hands-on experience with cell culture/ upstream processes and/or downstream processes in a manufacturing or development environment.
  • Has knowledge of cGMPs

Key Skills and Competencies

  • Strong technical knowledge and expertise in process understanding and application in biopharmaceutical processes with ability to coach junior Manufacturing Sciences engineers
  • Strong analytical skills including demonstration of systematic evaluation of potential issues, correlation or cause and effect relationships, root cause analysis methodology.
  • Good communication skill
  • Willingness to learn
  • Team worker/ able to work in matrix environment
  • Independent worker/ Self starter

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Empowering our people to shine:

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, or any other characteristic protected by law.


SGP - Singapore - Woodlands

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Full time
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Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.
  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.
  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 17 companies to receive Top Global Employer® status for 2024.
  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.
  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

What we believe in

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

  • Integrity

  • Fairness

  • Honesty

  • Perseverance

We're Steadfast In Our Commitment to Four Key Imperatives


Responsibly translate science into highly innovative medicines and accelerate access to improve lives worldwide.


Create an exceptional people experience.


Protect our planet.

Data & Digital

Transform Takeda into the most trusted, data-driven, outcomes-based biopharmaceutical company.

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About our location

Singapore, Singapore

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